红景天苷大孔吸附树脂纯化工艺研究  

Purification technology of salidroside by microporous adsorption resin

作　　者：闵建华 章振鹏 孟亚会 曹旻旻 朱锦章 向飞军 

机构地区：[1]康美药业股份有限公司,广东揭阳515300

出　　处：《中草药》2013年第11期1426-1430,共5页Chinese Traditional and Herbal Drugs

摘　　要：目的筛选红景天苷的大孔树脂纯化工艺。方法以红景天苷质量浓度为指标,考察多种型号大孔吸附树脂纯化红景天苷的吸附及洗脱条件。结果 SP-825型大孔吸附树脂为分离纯化红景天苷的最佳大孔吸附树脂,最佳工艺:上样红景天苷质量浓度为1.713～2.570 g/mL,洗脱剂为10%乙醇,洗脱剂用量为30 BV,体积流量为2 BV/h。结论 SP-825型大孔吸附树脂能显著提高样品液红景天苷的纯度,具有吸附量大、洗脱率高、经济环保等优点,适合于规模化生产。Objective To optimize the purification technology of salidroside with macroporous adsorption resin. Methods The absorption and elution conditions of salidroside purificatin by various macroporous adsorption resins were investigated with the content of salidroside as index. Results SP-825 type macroporous adsorption resin was the best choice for the purification of salidroside. The optimized parameters were as follows： the content of salidroside at 1.713--2.570 g/mL, eluting solvent of 10% aqueous ethanol, volume flow at 2 BV/h, and eluant volume at 30 BV. Conclusion SP-825 type macroporous adsorption resin could significantly increase the purity of salidroside with the advantage of high absorption, high elution rate, low cost, environment friendly, and being applicable for the production in large scale.

关 键 词：红景天 红景天苷 大孔吸附树脂 纯化工艺 洗脱剂 

分 类 号：R284.2[医药卫生—中药学]