酿酒酵母DNA损伤检查点Rad53活性的调节  

Regulation mechanism of Rad53 in Saccharomyces cerevisiae

作　　者：冯金荣[1] 于立权[2] 段义农[1] 

机构地区：[1]南通大学医学院病原生物学系,南通226001 [2]黑龙江八一农垦大学生命科学技术学院,大庆163319

出　　处：《生命的化学》2013年第3期250-254,共5页Chemistry of Life

基　　金：国家自然科学基金项目(31100112);南通市应用研究计划项目(BK2011030);江苏省高校优势学科建设工程资助项目

摘　　要：在酿酒酵母(Saccharomyces cerevisiae)中,Rad53作为最重要的检查点之一,对于维持细胞周期的正常运行具有重要意义。当发生DNA损伤后,细胞通过不同途径激活Rad53,进而激活下游的一些损伤修复基因,引发细胞周期阻滞从而修复损伤。当DNA损伤被修复后,Rad53需要适时失活,细胞周期才能恢复正常。对酿酒酵母Rad53的活性调节机制进行综述,将为深入研究其他生物的DNA损伤修复调节机制提供新的视角。The Rad53, one of the most important DNA damage checkpoint kinases in Saccharomyces cerevisiae, plays an important role on regulating the cell cycle. In face of DNA damage and replication stress, Rad53 will be activated through different signal pathways inside yeast cells. Then, the activated Rad53 can improve the transcription and expression of some target genes and finally arrest the cell cycle progression to facilitate the repair process. After successful repairment, the Rad53 should be deactivated to restart normal cell cycle progression. The review on the regulation mechanism of Rad53 in Saccharomyces cerevisiae will provide new insights into the cellular DNA damage and repair mechanism of some other species.

关 键 词：细胞周期检查点 DNA损伤 Rad53 蛋白磷酸酶 

分 类 号：Q343[生物学—遗传学]