快速膜乳化法制备尺寸均一PELA多孔微球及其孔径调控  

Preparation of Uniform-sized Porous PELA Microspheres and Their Pore Size Control

作　　者：张慧霞[1,2] 韦祎[2] 王玉霞[2] 阮燕晔[1] 马光辉[2] 

机构地区：[1]沈阳农业大学,辽宁沈阳110161 [2]中国科学院过程工程研究所生化工程国家重点实验室,北京100190

出　　处：《过程工程学报》2013年第3期466-473,共8页The Chinese Journal of Process Engineering

基　　金：国家自然科学基金资助项目(编号:51173187;20706053)

摘　　要：采用快速膜乳化法,以二氯甲烷为油相,通过溶剂挥发制孔,在室温下制备了一系列聚乙二醇聚乳酸共聚物(PELA)多孔微球.结果表明,优化的制备条件为:搅拌速度250r/min、油相中PELA浓度50g/L、水/二氯甲烷/PVA水溶液体积比1:2.5:25及mPEG:PLA分子量比1:14,在该条件下可制备粒径均一、尺寸可控的PELA多孔微球,且孔径较大,孔径最大为15.0nm,属介孔材料,可用于蛋白多肽类药物的吸附.Uniform-sized poly（ethylene glycol-co-lactide） （PELA） microspheres were prepared by a combined method of solvent evaporation and Shirasu porous glass membrane emulsification at room temperature with dichloromethane as oil phase. The results show that the suitable conditions to prepare the larger pore size and uniform-sized PELA microspheres are： stirring speed 250 r/min, PELA concentration in oil phase 50 g/L, volume ratio of water/dichloromethane/PVA solution 1：2.5：25, and molecular weight ratio of monomethoxy-poly（ethylene glycol） to poly（lactide acid） 1：14. The average pore size of final microspheres is 15 nm, belonging to the mesoporous material, which can be used as drug carrier to adsorb protein or peptide drugs.

关 键 词：PELA 多孔微球 快速膜乳化 溶剂挥发 载药微球 

分 类 号：R944[医药卫生—药剂学]