国产辛伐他汀治疗高脂血症疗效分析  

The Efficacy of Domestic Simvastatin in Treatment of Primary Hyperlipidemia

作　　者：钱卫冲[1] 黄峻[1] 王海燕[1] 廖静[1] 陈建国[1] 段宝祥[2] 罗骏[2] 施广飞[3] 吉庆文 

机构地区：[1]南京医科大学第一附属医院心脏科,南京210029 [2]南京医科大学附属南京第一医院心脏科,南京210006 [3]南京市鼓楼医院心脏科,南京210008

出　　处：《南京医科大学学报（自然科学版）》2000年第5期350-352,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的　评价国产辛伐他汀调节血脂的疗效及安全性。方法　 12 2例原发性高脂血症病人随机分入国产辛伐他汀 (6 1例 )组和进口辛伐他汀 (舒降之 ,6 1例 )组。剂量 10mg ,每日 1次 ,疗程 12周。结果　辛伐他汀组降低胆固醇、甘油三酯和动脉粥样硬化指数的有效率分别为 86 .9%、6 5 .6 %和 73.8% ,与进口辛伐他汀组无显著差异。两组不良反应发生率分别为13 1%和 16 4% ,无显著差异。结论　国产辛伐他汀治疗高脂血症与进口辛伐他汀一样有效、安全。Objective To evaluate the efficacy and safety of d om estic simvastatin. Methods 122 patients with primary hyperlipidemia w ere randomly received domestic simvastatin or ZOCOR (MSD) in daily dose of 10 mg for 12 weeks. Results After 12 weeks treatment, the total response r ates for TC, TG and TC-HDL-c/HDL-c were 86 9%,65.6% and 73.8%, respectively in domestic simvastatin group. There was no significant difference in response r ates between two groups, and so did the rates of adverse reactions (13.1% vs 16. 4%). Conclusion Domestic simvastatin is an effective and safe drug i n treating hyperlipidemia.\;

关 键 词：辛伐他汀 高脂血症 药物疗法 疗效 

分 类 号：R972.6[医药卫生—药品] R589.205[医药卫生—药学]