基于主成分分析和LS、Lasso对高血压患者脉诊信息特征分析研究  

Research of Features in the Pulse Waves of HBP Patients based on Principal Component Analysis and LS,Lasso

作　　者：薛利媛[1] 汪南玥[1] 于友华[1] 黄大威[1] 林谦[2] 闪增郁[1] 李同达[3] 陈燕萍[1] 陈岩[1] 

机构地区：[1]中国中医科学院医学实验中心,北京100700 [2]北京中医药大学附属东方医院,北京100078 [3]中国中医科学院基础理论研究所,北京100700

出　　处：《中国中医基础医学杂志》2013年第6期660-663,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家"十一五"科技支撑计划项目-中医四诊信息采集和证候分类技术项目(2006BAI08B01-02);基本科研业务费课题-脉搏波与脏腑功能状态关联关系研究项目(ZZ2006043);基本科研业务费课题-中医脉诊信息采集与管理分析系统的建立与完善(ZZ2010009)

摘　　要：目的:分析高血压患者的脉诊信息特征。方法:分别采集高血压患者的脉诊信息并与正常人对照进行分析。在对脉诊信息预处理后选取连续多个周期的脉搏波作为研究对象,建立数学模型并获取193个特征参数进行特征分析,分别进行主成分分析和LS、Lasso分类判决,并获得高血压患者脉诊信息的变化特征。结果:高血压患者的脉诊信息与正常人比较有较明显的差异,主成分分析的判决准确率为81%,7参数的LS回归判决准确率为93%。Lasso识别准确率为82%。其特征参数为时域参数h1和左关与右尺的频域参数中。结论:高血压患者机体的病理变化可以在桡动脉脉诊信息的时域与频域参数中得到体现并在诊脉的不同部位呈现较强的特征性。本研究为中医"独取寸口"的诊脉方法提供了一定的科学依据,并在一定程度上为中医分寸、关、尺不同部位的诊脉方式提供了科学基础。Objective： To study the features in the pulse waves of HBP patients.Methods： To collect the pulse waves of HBP patients and compare them with normal volunteers.We choose continuous cycles waves with different period length and then do the LSQ regression by 12 harmonics fitting which are correspond with every cycle lengths to build mathematical model and extract 193 parameters after pretreatment,then do principal component analysis and regression for classification and identification to find the features of HBP patients pulse waves by EFBLS.Result： There are significant differences between HBP patients pulse waves and the normal volunteers＇and the accurate rate is 81% to identify by principal component analysis,the accurate rate of LSQ regression by 7 features is 93%,of Lasso is 82%.And the features distribute at different places in radial artery called ＂zuoguan＂ and ＂youchi＂ in pulse-diagnosis of TCM.Conclusion： Pathological changes of HBP patients can embody in pulse waves we collected from the radial artery and the characters of the waves change regularly in special places.This research can offer some scientific basis for taking pulse in radial artery in TCM,also for the method of feeling different places when pulse-taking.

关 键 词：高血压 脉诊信息 分类判决 主成分分析 最小二乘回归 套索回归 

分 类 号：R544.1[医药卫生—心血管疾病]