尼莫地平辅助卡马西平治疗癫痫  

Nimodipine supplement during carbamazepine therapy of epilepsy

作　　者：解旭东[1] 冀风云[1] 王婷[1] 

机构地区：[1]中国人民解放军252医院神经内科,河北保定071000

出　　处：《中国新药与临床杂志》2000年第2期114-116,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的：研究不同剂量尼莫地平辅助治疗癫痫的疗效。方法：９２例癫痫病人，男性５４例，女性３８例，年龄（２９± ｓ ７） ａ， １８～５７ ａ，在卡马西平治疗至少３ｍｏ后，随机分为２组添加尼莫地平治疗。大剂量组（４６例）口服尼莫地平 ６０ ｍｇ， ｑ ６ ｈ；小剂量组（４６例）口服尼莫地平 ２０ ｍｇ， ｑ ８ ｈ，共 ３ ｍｏ。结果：大剂量组每人癫痫发作次数明显减少［治疗前（ １７ ± ７）次；治疗后（８±６）次， Ｐ＜ ０． ０１］，总有效率４６％。小剂量组每人癫痫发作次数明显减少［治疗前（１８±８）次；治疗后（６±６）次，Ｐ＜０．０１］，总有效率１７％。大剂量组与小剂量组每月发作次数比较差异有非常显著意义（ Ｐ＜ ０． ０１）。结论：尼莫地平辅助治疗癫痫有效，口服 ６０ ｍｇ， ｑ ６ ｈ疗效较好。AIM: To study the adjuvant effect of nimodipine in carbamazepine therapy of epilepsy. METHODS: Ninety-two Patients were randomized into two groups to received nimodipine as an add-on therapy in 3 mo: High dosages group(60 mg, po, q 6 h),low dosages group (20 mg, po, q 8 h). All patients had being received Carbamazepine more than 3 mo RESULTS: In high dosages group, seizure frequency was decreased >=50% in 21 patients totally (46% ). It was in & patients totally(17% ) in low dosages group. Results of high dosages group was better(p<0. 05 ). CONCLUSIONS: Nimodipine Potentiated the Carbamazepine treatment of epilepsy.

关 键 词：尼莫地平 卡马西平 癫痫 药物疗法 联合用药 

分 类 号：R972.6[医药卫生—药品] R742.105[医药卫生—药学]