哮喘易感基因多态性与哮喘预测指数阳性婴幼儿喘息的相关性  

Correlation of asthma susceptibility gene polymorphisms with API positive infantile wheezing

作　　者：陈虹[1,2] 刘海沛[1,2] 鲍一笑[1,2] 华丽[1,2] 

机构地区：[1]上海交通大学医学院附属新华医院儿童呼吸科 [2]上海交通大学哮喘诊治中心,上海200092

出　　处：《临床儿科杂志》2013年第6期547-550,共4页Journal of Clinical Pediatrics

基　　金：国家自然科学基金面上项目(No.30972750);上海市科学技术委员会医学重大项目(No.10DZ1951000);上海市卫生局青年科研项目(No.2010Y140)

摘　　要：目的探讨3个哮喘易感基因单核苷酸多态性(SNPs)位点与哮喘预测指数(API)阳性婴幼儿喘息的相关性。方法将201例喘息婴幼儿分为API阳性组(68例)和API阴性组(133例)。选取儿童哮喘易感基因SNPs位点ADRβ2R16G、FcεR1 E237G和IL13 A2044G,采用TaqMan探针法对两组患儿进行基因分型,分别比较上述基因多态性位点在阳性组和阴性组间的分布差异。结果多态性位点FcεR1 E237G AG杂合子在API阳性组的频率明显高于阴性组(分别为41.2%和24.1%),差异有统计学意义(χ2=6.30,P=0.012,OR=2.21,95%CI=1.18～4.13),而ADRβ2 R16G和IL13 A2044G位点在两组间的分布差异无统计学意义(χ2=1.72、1.85,P均>0.3)。结论儿童哮喘易感基因单核苷酸多态性FcεR1 E237G AG杂合子与API阳性患儿喘息相关,未发现ADRβ2 R16G和IL13 A2044G多态性与API阳性患儿喘息相关。Objectives To investigate the correlation of three single nucleotide polymorphisms （SNPs） in asthma suscep-tibility genes with asthma predicting index （API） positive infantile wheezing. Methods Two hundreds and one wheezing infants were recruited and divided into two groups, API positive （n=68） or negative （n=133） groups. TaqMan probe was applied to detect the genotypes of three SNPs in childhood asthma susceptibility genes. They were ADRβ2 R16G, FcεR1 E237G and IL13 A2044G. The genotype distributions were analyzed and compared between the two groups. ResuRs The frequency of FcεR1 E237G AG heterozygote in the API positive group was significantly higher than that in the negative group （x^2=6.30, P=0.012, OR=2.21, 95%CI=1.18-4.13）, while no significant differences were found in the genotype distribution of ADRI32R16G and IL13A2044G between the two groups （x^2=1.72, 1.85 respectively; P〉0.3）. Conclusions Childhood asthma susceptibility SNP FceR1 E237G AG heterozygote is related to API positive infantile wheezing. ADRβ2 R16G and IL13 A2044G polymorphisms are not found associ-ated with API positive infantile wheezing in the present study.

关 键 词：哮喘 易感基因 婴幼儿喘息 哮喘预测指数 

分 类 号：R725.6[医药卫生—儿科]