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作 者:潘斌斌[1] 苏晓飞[1] 朱剑[1] 付丽媛[1] 郭琳[1] 夏斯桂[1] 马建华[1]
机构地区:[1]南京医科大学附属南京医院(南京市第一医院)内分泌科,南京医学硕士210012
出 处:《医学研究生学报》2013年第6期598-600,共3页Journal of Medical Postgraduates
基 金:江苏省科技发展计划项目(BK2010121)
摘 要:目的高血压合并不同糖耐量在临床上颇为常见。文中探索高血压合并不同糖耐量人群肾小球滤过率差异,评估糖尿病合并糖代谢异常患者肾脏损伤的特点。方法通过测定204例高血压病程在10年内合并空腹血糖受损(impaired fast glucose,IFG)、糖耐量异常(impaired glucose tolerance,IGT)、糖调节受损(impaired glucose regulate,IGR)及糖尿病(diabetes mellitus,DM)患者血清肌酐,进一步通过MDRD方程计算其肾小球滤过率(estimate glomerular filltration,eGFR),通过组间比较高血压合并不同糖代谢人群eGFR水平。结果 eGFR水平在IGT、IFG、IGR、DM不同人群均值分别为(87.95±26.27、93.46±18.91、98.94±24.14、105.50±31.09)ml/(min.1.73m2),呈逐渐上升趋势,组间比较IGT组与DM组之间存在统计学差别(P<0.05);以eGFR>125 ml/(min.1.73m2)为高eGFR,共计25例患者,其中IFG 3例,IGT1例,IGR组8例,DM组13例,组内相应比率分别为6.8%、5.9%、8.2%、28.9%,χ2检验比较发现4组间在eGFR上存在统计学差别(P<0.01)。结论高血压病程在10年内的人群合并糖代谢异常患者存在超滤状态;且DM组人群超滤状态发生率高于糖尿病前期人群。ObjectiveHypertensive complicated with different glucose tolerance is common in clinic. The aim of this study is to explore differences of glomerular filtration rates in hypertensive patients accompanied with different glucose tolerance and evaluate the characteristics of the kidney damage in these people.Methods204 hypertensive patients with durations less than 10 years were recruited.The serum creatine of the patients were tested and estimate glomerular filltration(eGFR) rates were calculated through equation of MDRD.Then eGFR of different glucose tolerance patients were compared.ResultsMeans of eGFR in groups of impaired glucose tolerance(IGT),impaired fast glucose(IFG), impaired glucose regulate(IGR),diabetes mellitus(DM) were as follows, (87.95±26.27, 93.46±18.91, 98.94± 24.14, 105.50±31.09)ml/(min·1.73m2),which showed rising trends.Comparisons among groups showed marked difference between IGT and DM(P〈0.05).High eGFR was set with the value more than 125ml/(min·1.73m2).Twenty-five patients had high eGFR with three in IFG, one in IGT, eight in IGR, thirteen in DM. And the rate were 6.8%, 5.9%, 8.2%, 28.9%. The χ2-test showed statistics significant differences between groups(P〈0.01).ConclusionPatients with durations of hypertension less than 10 years existed hyperfiltration. The incidence of hyperfiltration in patients with diabetes is higher than patients with prediabetes.
关 键 词:高血压 糖耐量异常 糖尿病 肾小球滤过率 高滤过状态
分 类 号:R544.1[医药卫生—心血管疾病]
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