激素治疗对更年期综合征患者生存质量的影响  

Impact of hormone therapy on quality of life of women with menopausal syndrome

作　　者：殷冬梅[1] 刘真[2] 阮祥燕[1] 王娟[1] 

机构地区：[1]首都医科大学附属北京妇产医院妇内分泌科,北京100025 [2]首都医科大学附属北京妇产医院科研处,北京100025

出　　处：《首都医科大学学报》2013年第3期428-431,共4页Journal of Capital Medical University

基　　金：北京市自然科学基金(3082011);首都医科大学基础临床合作研究基金(12JL65)~~

摘　　要：目的综合评价激素补充治疗对更年期综合征患者生理、心理的生存质量的影响。方法观察性研究125例更年期综合征患者,按有无经过激素治疗分为2组:A组65例患者未经任何激素类药物治疗,B组60例经过了6个月的激素补充治疗;测量基本参数,并填写改良Kupperman评分、焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)、绝经期生存质量量表(menopause-specific quality of life questionnaire,MENQOL)。结果 60例实施激素补充治疗的更年期女性的Kupperman指数,SAS、SDS、MENQOL的结果均显著低于未经治疗者;35例患者治疗前后4项量表评分差异也有统计学意义。结论激素补充治疗不仅可以显著缓解患者围绝经期出现的躯体不适,还能够改善焦虑、抑郁程度,提高更年期综合征患者的生存质量。Objective To evaluate the effects of hormone replacement therapy on climacteric patient＇s physical condition as well as psychology. Methods An observational study on 125 patients with climacteric syndrome was conducted, the patients were divided into two groups according to whether they were treated with hormone therapy： group A had 65 patients without any hormone therapy, group B had 60 patients who received hormone replacement therapy for 6 months ; the basic parameters and complete Kupperman scale, Self-Rating Anxiety Scale （ SAS ）, Self-Rating Depression Scale （ SDS ） and Menopause-specific Quality of Life Questionnaire （ MENQOL ） were applied for evaluation. Results In the 60 patients with menopausal syndrome who received hormone replacement therapy, the scores of Kupperman index, SAS, SDS, MENQOL were significantly lower than those of the untreated patients＇ group; of whom 35 patients showed significant difference between the scores obtained before and after treatment in 4 scalel. Conclusion Hormone replacement therapy could significantly alleviate the perimenopausal physical discomfort, but also could improve anxiety and depression,therefore, could improve the quality of life of menopausal women.

关 键 词：更年期 生存质量 激素补充治疗 

分 类 号：R246.3[医药卫生—针灸推拿学]