羟基喜树碱灌胃密集式低剂量化疗对小鼠生存期的影响  

Effects of Hydroxycamptothecine by Gavage with Metronomic Chemotherapy on Survival Time of Mice

作　　者：顾红燕[1] 孙路路[1] 郭青龙[2] 赵丽[2] 

机构地区：[1]首都医科大学附属北京世纪坛医院药剂科,北京100038 [2]中国药科大学江苏省肿瘤发生与干预实验室,南京210009

出　　处：《中国药房》2013年第25期2320-2322,共3页China Pharmacy

基　　金：首都医科大学附属北京世纪坛医院科研课题(No.2009-C17)

摘　　要：目的:探讨羟基喜树碱(HCPT)灌胃密集式低剂量化疗(MC)对小鼠生存期的影响。方法:将接种有肝瘤株H22的小鼠随机分为A(阴性对照)组、B[HCPT-脉冲式高剂量化疗(MTD)]组和C、D(高、低剂量HCPT-MC)组,每组10只。给药方案分两个阶段,第一阶段为MTD,A组小鼠腹腔注射地塞米松0.5mg/kg,B、C、D组小鼠灌胃HCPT10mg/kg,隔日给药1次,给药4次;第二阶段为MC,C、D组小鼠灌胃HCPT0.05、0.1mg/kg,A组小鼠同步给予地塞米松,B组小鼠给予生理盐水。共给药27d,检测给药第8、15、22、27天时各组小鼠存活率、体质量和瘤体积。结果:与A组比较,D组小鼠各时间点存活率均明显增加(P<0.05),C组小鼠于给药第22天时存活率为0,B组小鼠各时间点存活率无明显差异(P>0.05)。与B组比较,C组小鼠给药第15、22、27天时体质量均明显降低,第27天时瘤体积明显减小。结论:HCPT灌胃MC能有效延长小鼠生存期,但需谨慎设计MC给药剂量。OBJECTIVE：To investigate the effects of hydroxycamptothecine（HCPT）by gavage with metronomic chemotherapy（MC）on survival time of mice. METHODS：H22 tumor strain bearing mice were randomly divided into group A（negative control group）,group B [HCPT-maximum tolerant dose（MTD）],group C（low-dose HCPT-MC）and group D（high-dose HCPT-MC） with 10 mice in each group. Those groups received MTD firstly：group A was given dexamethasone 0.5 mg/kg intraperitoneally, and group B,C and D were given HCPT 10 mg/kg intragastrically every 2 days for 4 times. MC therapy was second stage：group C and D were given HCPT 0.05 and 0.1 mg/kg,group A with dexamethasone and group B with normal saline. The administration lasted for 27 days. The survival rate,body weight and tumor volume of mice were determined at 8th,15th,22nd and 27th after medication. RESULTS：Compared with group A,survival rate of mice in group D increased significantly（P〈0.05）;none of mice in group C survived at 22nd after medication;there was no significant difference in survival rate of mice in group B（P〈0.05）. Compared with group B,body weight of mice in group C decreased significantly at 15th,22nd and 27th day after medication,and the tumor volume decreased significantly at 27th day. CONCLUSIONS：Intragstric administration MC of HCPT can prolong the survival time of mice,but it should be careful to confirm the dose of MC.

关 键 词：密集式低剂量化疗 脉冲式高剂量化疗 羟基喜树碱 小鼠 生存期 

分 类 号：R965[医药卫生—药理学]