金类配合物的抗肿瘤活性研究进展  

Advances in Research on the Anti-tumor Activities of Gold Complexes

作　　者：祁欢欢[1] 孙建国[1] 彭英[1] 冯冬[1] 王广基[1] 

机构地区：[1]中国药科大学药代动力学重点实验室,江苏南京210009

出　　处：《药学进展》2013年第6期265-273,共9页Progress in Pharmaceutical Sciences

基　　金：科技基础设施建设计划-江苏省创新平台提升项目(No.BM2012012);"十一五"重大新药创制项目(No.2009ZX09102-055)

摘　　要：金配合物是以金离子为中心所形成的一类配合物,其中金离子具有特殊的电子结构,故在氧化还原反应中非常活跃,可使配合物与细胞内还原性生物大分子发生相互作用,进而发挥药理活性。近来,研究人员通过对与金离子配位结合的配体进行替换或修饰,设计并合成了一系列性质稳定、功能多样化的金配合物。对几种抗肿瘤活性显著的+1和+3价金配合物及其研究进展进行综述。[ Abstract] Gold complexes are a kind of compounds which contain gold ions in the center of mole- cules. The gold ions have special electronic structure so their chemical property is quite active. Based on this, the gold complexes can easily act on the reductive biomacromolecules in cells, so as to generate phar- macological activities. Recently, the researchers have designed and synthesized a series of gold complexes which have stable properties and multiple functions, by means of replacing and modifying the ligands in the complexes. The advances in research on the Au（I） and Au（III） complexes which show promising anti- tumor activities have been reviewed in this paper.

关 键 词：金配合物 化学特性 抗肿瘤活性 药动学 作用机制 

分 类 号：R285[医药卫生—中药学]