不同剂量叶酸对H型高血压血浆同型半胱氨酸水平的影响  

Effect of different dose of folic acid on the plasma homocysteine in patients with hyperhomocysteinima-related hypertention

作　　者：余泳[1] 王晓明[1] 陈月婵[1] 

机构地区：[1]广东省佛山市南海区罗村医院内科,528226

出　　处：《中国实用医刊》2013年第13期10-11,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察不同剂量叶酸对H型高血压患者血浆同型半胱氨酸水平的影响。方法选择150例H型高血压病患者随机分为A、B、C三组，每组50例。用药剂量：A组给予叶酸5mg／a，B组给予叶酸10mg／d，c组给予叶酸15mg，连续给药4周，治疗前后检测血浆Hey浓度。结果三组治疗后血浆Hey浓度皆明显下降，前后自身比较差异有统计学意义（P〈0．001）。三组间比较差异无统计学意义（P〉0．05）。结论叶酸对降低H型高血压病患者血浆Hey有明显效果，但叶酸〉5mg／d后增加叶酸剂量对于降低Hcy程度无明显效果。cystelne in patients Objective with hyperh To observe the effect omocysteinima-related of different dose of folic hypertention. Methods acid on the plasma homo- One hundred and fifty patients with hyperhomocysteinima-related hypertention were randomly divided into 3 groups, 50 cases in each group. Group A was given folic 5 mg/d; group B was given folic acid 10 mg/d; group C was given folic acid 15 mg/d; The plasma homocysteine（Hcy） concentration was detected before and after 4 weeks treatment. Results After 4 weeks treatment, the levels of plasma Hcy all significantly decreased in 3 groups（ P all 〈 0. 001 ）, compared with the level of prior treatment. But there was no difference among the 3 groups after the treatment （ P all 〉 0.05 ）. Conclusions The plasma homocys- teine in patients with hyperhomocysteinima-related hypertention was decreased after the treatment of folic acid. The degree of the homocysteine decreased has no relationship with dose of the medicine.

关 键 词：叶酸 剂量 H型高血压 同型半胱胺酸 

分 类 号：R544.1[医药卫生—心血管疾病]