唑来膦酸联合用药治疗老年女性骨质疏松患者的疗效观察  

Observation of the Effect for Elderly Women's Osteoporosis Using Zoledronic Acid Combination

作　　者：郑彬彬[1,2,3] 叶曼[1,2,3] 李晓静[1,2,3] 

机构地区：[1]温州医学院附属第二医院麻醉科,浙江温州325027 [2]温州医学院疼痛医学研究所,浙江温州325027 [3]中华医学会疼痛学会第八临床中心,浙江温州325027

出　　处：《中国现代应用药学》2013年第6期682-684,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的探讨唑来膦酸及鲑鱼降钙素联合钙尔奇D、阿法骨化醇、复方骨肽注射液治疗老年女性骨质疏松症的疗效。方法选取40例老年女性骨质疏松性胸腰椎疼痛患者随机分为两组,对照组服用钙尔奇D片(钙尔奇D600)、阿法骨化醇,鲑鱼降钙素注射液、治疗组在对照组的基础上加用唑来膦酸注射液和复方骨肽注射液,两组均连续治疗半年,观察治疗前后的骨密度和疼痛变化。结果两组治疗后骨密度均明显上升。与治疗前比较差异有统计学意义(P<0.05)。治疗后治疗组骨密度明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组VAS评分均明显下降,与治疗前比较差异有统计学意义(P<0.05),治疗后治疗组VAS评分下降程度高于对照组,差异有统计学意义(P<0.05)。结论唑来膦酸及鲑鱼降钙素注射液联合钙尔奇D、阿法骨化醇、复方骨肽注射液治疗老年女性骨质疏松性胸腰椎压缩性骨折患者安全、临床疗效好,优于钙尔奇D片(钙尔奇D600)、阿法骨化醇,鲑鱼降钙素注射液三者合用的治疗方案。OBJECTIVE To investigate the effect of zoledronic acid combinated salmon calcitonin see calcimar, Caltrate D alfacalcidol and bone-peptide injection cure old osteoporosis. METHODS Forty cases of thoracolumbar pain of osteoporosis patients were randomly divided into two groups： The control group received salmon calcitonin see calcimar, Caltrate D, alfacalcidol, the therapeutic group received zoledronic acid and bone-peptide injection besides salmon calcitonin see calcimar, Caltrate D, calcitonin. The two groups received six months therapia. Observe the BMD and pain before and after the therapy. RESULTS The BMD of two groups both rised（P〈0.05）. The BMD of therapeutic group is higher than the control （P〈0.05）. The VAS score of two groups both descend（P〈0.05）. The VAS score of therapeutic group is lower than the control （P〈0.05）. CONCLUSION Zoledronic acid combinated salmon calcitonin see calcimar, Caltrate D, alfacalcidol and bone-peptide injection is a safe curation for old osteoporosis, and more effective than the curation used salmon calcitonin see calcimar, Caltrate D and alfacalcidol together.

关 键 词：老年女性骨质疏松 唑来膦酸 联合用药 

分 类 号：R969.4[医药卫生—药理学]