代谢组学在慢性气道炎症性疾病中的研究进展  

Application of metabolomics approaches to study of chronic respiratory inflammatory diseases

作　　者：厉蓓[1] 董竞成[1] 

机构地区：[1]复旦大学附属华山医院中西医结合科,上海200040

出　　处：《国际呼吸杂志》2013年第12期924-930,共7页International Journal of Respiration

基　　金：基金项目：国家重点基础研究发展计划973计划项目（2009CB523000）;国家自然科学基金资助项目（81173390/H2902）

摘　　要：代谢组学是研究生物体被扰动后内源性代谢物变化规律的系统科学，其在慢性气道炎症性疾病如支气管哮喘、慢性阻塞性肺疾病中的应用研究成为热点，有望通过对慢性气道炎症性疾病患者的代谢轮廓分析，寻找到有意义的生物标记物并探索疾病的发病机制。本文就研究现状作一综述，并展望其发展前景。Metabolomics is a systematic science that mainly studies the dynamic changes of endogenous metabolites after a biological system is stimulated or disturbed. Its application in chronic respiratory inflammatory diseases like chronic obstructive pulmonary disease and asthma has increasingly been explored,with an attempt to find valuable biomarkers and explore the underlying pathogenesis of chronic respiratory inflammatory diseases by profiling the metabolism in these patients. This article summarizes recent advances in this topic and outlines prospects for future developments.

关 键 词：代谢组学 慢性气道炎症性疾病 支气管哮喘 慢性阻塞性肺疾病 

分 类 号：R5[医药卫生—内科学]