丙型病毒性肝炎病毒重叠结核杆菌感染患者的自然杀伤性细胞的分析  

Impact of co-infection of hepatitis C virus and Mycobacterium tuberculosis on patient's natural killer cell

作　　者：陈建萍[1] 许文芳[2] 

机构地区：[1]杭州市第三人民医院检验科,浙江杭州310009 [2]绍兴市第六人民医院检验科

出　　处：《疾病监测》2013年第5期360-361,共2页Disease Surveillance

摘　　要：目的研究丙型病毒性肝炎(丙肝)重叠结核杆菌感染对NK细胞的作用,探讨NK细胞在丙肝重叠结核杆菌感染患者体内的免疫学功能。方法选择单纯丙肝感染患者47例,单纯结核杆菌感染患者66例,丙肝重叠结核杆菌感染患者27例,应用流式细胞仪检测患者外周血中NK细胞的数量及分泌的细胞因子的含量。结果丙肝重叠结核杆菌感染患者的NK细胞数量明显低于单纯感染组,二者比较差异有统计学意义(P<0.05),IFN-γ的含量亦明显低于单纯感染组,差异有统计学意义(P<0.05)。结论重叠感染组的NK细胞数量及活性下降,细胞免疫机制参与了丙肝重叠结核杆菌感染的发病及发展。Objective To study the impact of co-infection of hepatitis C virus and Mycobacterium tuberculosis on patient's natural killer(NK) cells and explore the immunological function of NK in the patients co-infected with hepatitis C virus and M.tuberculosis.Methods Totally 47 patients with simple hepatitis C infection,66 patients with simple infection of M.tuberculosis and 27 patients co-infected with hepatitis C virus and M.tuberculosis were selected.The NK cell counts and secreted cytokines contains in theirs peripheral blood were detected with flow cytometry(FCM).Results The NK cell counts and IFN-γ contains in peripheral blood of the patients co-infected with hepatitis C virus and M.tuberculosis were obviously lower than those of the patients with simple hepatitis C infection or simple M.tuberculosis infection,the differences were statistical significant(P<0.05).Conclusion The co-infection reduced the NK cell counts and activity in peripheral blood.Cellular immunity was involved in the development and progress of co-infection of hepatitis C virus and M.tuberculosis,which should be considered in clinical diagnosis and treatment.

关 键 词：丙型病毒性肝炎病毒 结核杆菌 重叠感染 NK细胞 

分 类 号：R512.63[医药卫生—内科学]