超声造影评价兔脂肪肝及正常肝背景炎性假瘤血流灌注的研究  

Comparative study of inflammatory pseudoneoplasm of the liver in rabbits with fatty liver and normal liver by contrast-enhanced ultrasonography

作　　者：张炎晶[1] 刘利平[1] 鲁琴[1] 赵育芳[1] 郝艳红[1] 徐琨[1] 曹成[1] 

机构地区：[1]山西医科大学第一医院超声科,太原030001

出　　处：《中华超声影像学杂志》2013年第6期525-529,共5页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金面上项目（81171361）;山西省人事厅留学人员择优资助项目（2011762）

摘　　要：【摘要】目的应用实时超声造影成像技术结合时间一强度曲线观察兔脂肪肝及正常肝背景下肝炎性假瘤的血流灌注特征。方法脂肪肝及正常肝背景下炎性假瘤实验兔各10只，共种植39个结节，经耳缘静脉团注超声造影剂SonoVue后，应用CnTI低机械指数实时超声造影成像技术结合QontraXt定量分析软件，观察三期肝炎性假瘤结节及周围肝组织的动态增强过程。结果①肝炎性假瘤超声造影可表现为4种形式：1个为无明显增强型（I型），19个为等增强型（1I型），6个为低增强型（11I型），13个为快速廓清型（IV型）；②与正常肝背景相比，脂肪肝背景造影到达时间晚，峰值强度低，差异均有统计学意义（P〈0．05）；③两组炎性假瘤与其周围肝实质相比，到达时间晚，峰值强度低，曲线尖度高，差异均有统计学意义（P〈0．05）；④脂肪肝背景下的炎性假瘤与正常肝背景下的炎性假瘤相比，各超声造影参数差异均无统计学意义（P〉0．05）。结论肝炎性假瘤因不同的病理成分，超声造影可表现为多种灌注形式，超声造影定量分析可更精确反映肝炎性假瘤及不同肝背景的血流灌注情况。Objective To analyze hepatic inflammatory pseudoneoplasm with fatty liver and normal liver perfusion blood characteristics and quantitative parameters using real-time contrast enhanced ultrasound （CEUS） and time intensity curve. Methods Twenty rabbits （including ten with fatty liver and ten with normal liver） with thirty nine inflammatory pseudoneoplasm of the liver （IPL） were studied by low mechanical index CEUS with bolus injection of SonoVue via peripheral auricular vein and QontraXt quantitative analysis software. IPL contrast-enhanced ultrasound blood perfusion characteristics with two different liver background were analyzed. Results （1）According to the different pathological elements, IPL showed four kinds of CEUS types： one lesion showed absent contrast enhancement pattern （type Ⅰ ）, nineteen lesions showed iso enhancement pattern （type Ⅱ ）, six lesions showed hypo enhancement pattern （type Ⅲ）,thirteen lesions showed fast-in and fast-out pattern （type Ⅳ）. （2）Compared with normal liver, arrival time of fatty liver was later and its peak intensity was lower. （3）Compared with peripheral parenchyma,arrival time of IPL was later, peak intensity was lower and its sharpness was sharper （ P〈0.05）. （4）Between IPI. lesions with two different liver background,there was no significant difference about parameters of the time-intensity curve （ P 〈0.05）. Conclusions Due to different pathological elements,IPL lesions have multiform perfusion patterns in CEUS. CEUS and time intensity curve could provide enough perfusion information for IPL and liver parenchyma more accurately.

关 键 词：超声检查 微气泡 脂肪肝 肝疾病 肉芽肿 浆细胞 

分 类 号：R445.1[医药卫生—影像医学与核医学]