抗膜突蛋白抗体与急性冠状动脉综合征的相关性  

Relevance between moesin antibody and acute coronary syndrome

作　　者：杜峰[1] 毛华[1] 杨晓武[1] 夏晗[1] 朱晋坤[1] 文美[1] 刘廷筑[1] 

机构地区：[1]贵阳市第一人民医院心内科,贵阳550002

出　　处：《临床心血管病杂志》2013年第6期426-428,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨抗膜突蛋白抗体与急性冠状动脉(冠脉)综合征(ACS)及冠脉病变程度的相关性。方法:选择150例ACS患者,分为不稳定心绞痛(UA)组和急性心肌梗死(AMI)组。经冠脉造影按其病变程度分为单支病变、双支病变、3支病变及左主干病变3组,并计算相应的冠脉病变积分。同期选取冠脉造影排除冠心病者51例作为对照组。采用酶联免疫吸附试验(ELISA)检测入选者血清抗膜突蛋白抗体,观察各组抗膜突蛋白抗体阳性检出率及OD检测值;并对冠脉病变积分和抗膜突蛋白抗体的OD检测值进行相关性分析。结果:①ACS组抗膜突蛋白抗体阳性检出率及OD检测值显著高于对照组(P<0.01);②UA组的抗膜突蛋白抗体阳性检出率及OD检测值显著高于AMI组(P<0.05);③随着冠脉病变程度的加重,抗膜突蛋白抗体阳性检出率及OD检测值也逐渐升高,其中3支病变及左主干病变组与单支病变组比较差异也有统计学意义(P<0.05);④相关性分析显示,抗膜突蛋白抗体的OD检测值与冠脉病变积分呈显著正相关(r=0.601,P<0.01)。结论:抗膜突蛋白抗体可能是一种新的血管内皮持续损伤的标志物,有助于鉴别ACS的临床类型及判断冠脉血管的病变程度。Objective：To investigate the correlation between moesin antibody and acute coronary syndrome （ACS） and explore the relationship between moesin antibody and the severity of coronary artery lesion. Method：A total of 150 patients with ACS was divided into unstable angina （UA） group and acute myocardial infarction （AMI） group. Then all the patients were divides into three groups according to severity of coronary artery disease： single vessel group, double vessel group, three vessel and left main vessel group. Each patient was calculated the coronary artery stenosis score. Other 51 patients excluded coronary heart disease （CHD） through coronary angiography were selected into control group. Serum moesin antibody of all the patients were decteded by enzyme-linked immunosorbent assay （ELISA）, the moesin antibody positive expression rates and OD values in different groups were observed. The correlation between the coronary artery stenosis scores and the OD value of moesin antibody was analysed. Result：①The positive expression rate and OD value of moesin antibody in ACS group were significantly higher than those in control group （P〈0.01）. ②The positive expression rate and OD value in UA group were significantly higher than those in AMI group （P〈0.05）. ③In pace with the severe of coronary artery lesions, the positive expression rate and OD value of moesin antibody were gradually increased, and there was significant difference between three-vessel and left main vessel group and single-vessel group （P〈0.05）. ④Correlation analysis showed that there was significantly positive correlation between the OD value of moesin antibody and the coronary artery stenosis scores （r=0.601, P〈0.01）. Conclusion：Moesin antibody may be a new marker for chronic and sustained vascular endothelial injury, which could contribute to judge the clinical type of ACS and the severity of coronary artery lesions.

关 键 词：冠状动脉综合征 急性 膜突蛋白 抗膜突蛋白抗体 冠状动脉病变积分 

分 类 号：R543.3[医药卫生—心血管疾病]