血浆脑利钠肽与急性心肌梗死的相关性研究  

Relationship between plasma brain natriuretic peptide and acute myocardium infarction

作　　者：梁少兰[1] 李自成[2] 杜作义[1] 

机构地区：[1]广东省第二人民医院心内二科,广州510317 [2]广州暨南大学附属第一医院心内科

出　　处：《临床心血管病杂志》2013年第6期440-442,共3页Journal of Clinical Cardiology

基　　金：广东省科技计划项目(No:2010-1096-136);广州市科技计划项目(No:2010Y1-C941);暨南大学第一临床医学院重点学科基金(No:2010-4)

摘　　要：目的:探讨血浆脑利钠肽(BNP)与急性心肌梗死(AMI)的关系。方法:选择2010-01-2011-05入住我院的AMI患者112例,分别测定患者的血浆BNP水平、左心室舒张末径(LVEDd)及左心室射血分数(LVEF);分析不同血浆BNP水平情况下LVEDd与LVEF水平,以及不同罪犯血管对BNP、LVEDd与LVEF等的影响。结果:随着AMI患者血浆BNP浓度的升高,LVEDd增加,LVEF降低(均P<0.05);罪犯血管位于前降支较左旋支、回旋支患者的血浆BNP水平明显升高,LVEF明显降低,LVEDd增加(均P<0.05)。结论:血浆BNP水平可作为监测AMI患者心功能的重要指标之一。目的:探讨血浆脑利钠肽(BNP)与急性心肌梗死(AMI)的关系。方法:选择2010-01-2011-05入住我院的AMI患者112例,分别测定患者的血浆BNP水平、左心室舒张末径(LVEDd)及左心室射血分数(LVEF);分析不同血浆BNP水平情况下LVEDd与LVEF水平,以及不同罪犯血管对BNP、LVEDd与LVEF等的影响。结果:随着AMI患者血浆BNP浓度的升高,LVEDd增加,LVEF降低(均P<0.05);罪犯血管位于前降支较左旋支、回旋支患者的血浆BNP水平明显升高,LVEF明显降低,LVEDd增加(均P<0.05)。结论:血浆BNP水平可作为监测AMI患者心功能的重要指标之一。Objective：To investigate the relationship between plasma brain natriuretic peptide（BNP）and acute myocardium infarction（AMI）.Method：One hundred and twelve patients with AMI were admitted from January 2010to May 2011.Plasma BNP levels,left ventricular end-diastolic diameter（LVEDd）,and left ventricular ejec- tion fraction（LVEF）were determined.The variation of LVEDd and LVEF in patients with different BNP levels were analyzed.The the effect on BNP,LVEDd and LVEF in different culprit vessels also were evaluated.Result： With the plasma BNP levels rising,LVEDd increased and LVEF decreased（both P〈0.05）in patients with AMI. The plasma BNP level rised,LVEF decreased and LVEDd increased more obviously in left anterior descending artery than in left circumflex artery or right coronary artery（all P〈0.05）.Conclusion：The plasma BNP levels may as one of important index in monitoring heart function in patients with AMI.

关 键 词：心肌梗死 急性 脑利钠肽 罪犯血管 左心室射血分数心肌梗死 急性 脑利钠肽 罪犯血管 左心室射血分数 

分 类 号：R542.2[医药卫生—心血管疾病]