抗菌肽对热应激肉鸡生长性能及免疫器官的影响  

Effects of antibacterial peptides on growth performance and immune organs of broiler under heat stress condition

作　　者：包汇慧[1,2] 高贤彪[2] 陈建[2] 田纪景[2] 常玲玲[2] 肖鹏[2] 杜芳[2] 汪会玲[1] 耿雪[1] 佘锐萍[2] 

机构地区：[1]国家食品安全风险评估中心卫生部食品安全风险评估重点实验室,北京100021 [2]中国农业大学动物医学院,北京100193

出　　处：《中国兽医科学》2013年第6期623-628,共6页Chinese Veterinary Science

基　　金：国家自然科学基金项目(30270995;30471301);高等学校博士学科点专项科研基金项目(20070019035)

摘　　要：为了解抗菌肽在热应激条件下对肉鸡生长性能及免疫器官的影响,选用30只2周龄健康AA肉鸡,称重后随机分为3组:常温对照组、单纯热应激组、抗菌肽+热应激组,每组10只,热应激10d。结果,抗菌肽+热应激组与单纯热应激组比较,平均日增重及饲料转化率差异极显著(P<0.01);病理观察发现单纯热应激组肉鸡法氏囊充血、出血,淋巴滤泡星空样变,胸腺皮质区淋巴细胞坏死、排空,脾充血、淤血,淋巴细胞坏死,小肠黏膜水肿脱落,上皮层及固有层炎性细胞浸润;抗菌肽+热应激组无明显病变;免疫组化检测表明,抗菌肽+热应激组肉鸡胸腺、脾、法氏囊中热休克蛋白70(HSP70)的表达少于单纯热应激组。结果表明,在热应激条件下口服抗菌肽可以降低热应激对机体免疫器官的损伤,降低高温对肉鸡增重的影响。In order to verify if antimicrobial peptides（AMP） could modulate growth performance and immune function under heat stress condition,thirty 10-day-old Arbor Acre broiler chickens were randomly grouped into three groups with 10 of each, including control group, heat stress group and AMP treated group（2 mg per bird） with heat stress. Temperature was heated up for 10 days. In result, average body weight gain and FCR in AMP treated group under heat stress condition had significant difference compared to heat stress group （P〈0. 01）. Pathology observation and immunohistochemistry showed that injury degree and expression of heat stress protein 70 （HSP70） in the thymus, spleen and bursa of fabricius of AMP treated birds were lower compared to the heat stress group. In conclusion,AM may reduce injuries of immune organs caused by heat stress and increase a body weight gain in broilers.

关 键 词：抗菌肽 热应激 肉鸡 生长性能 免疫器官 

分 类 号：S859.796[农业科学—临床兽医学]