4-氨基吡啶缓释微丸的制备及体外释放度考察  

Preparation and in vitro release of 4-aminopyridine sustained-release pellets

作　　者：杨艳[1] 周郁斌[1] 关世侠[1] 袁中文[1] 叶小玲[1] 胡波[1] 

机构地区：[1]广州中医药大学中药学院,广州510006

出　　处：《中国新药杂志》2013年第12期1448-1451,共4页Chinese Journal of New Drugs

摘　　要：目的:制备一种4-氨基吡啶缓释微丸。方法:采用挤出-滚圆法制备4-氨基吡啶微丸,用丙烯酸树脂水分散体对其包衣,并考察微丸的体外释药。结果:制得的4-氨基吡啶缓释微丸圆整度好,大小均匀,在2 h内释药40.6%,剩余药物在随后的10 h内缓慢释放完全。结论:所制得的4-氨基吡啶缓释微丸体外释药缓慢、平稳,其制备工艺简便,易于操作。Objective： To prepare 4-aminopyridine sustained-release pellets. Methods： Extrusion-spher- onization technique was introduced to prepare 4-aminopy-ridine uncoated pellets and Eudragit dispersions were used as coating materials. The in vitro dissolution of the pellets was determined. Results： The prepared 4-aminop-yri- dine sustained-release pellets had a high roundness and the particle size was homogeneous. The release percentage was 40.6% in the first two hours and almost complete in the later ten hours. Conclusion： The release of 4-amin- opyridine from sustained-release pellets is slow and steady; and the preparation technology is easy to operate

关 键 词：4-氨基吡啶 缓释微丸 挤出-滚圆法 丙烯酸树脂 体外释放 

分 类 号：R943.41[医药卫生—药剂学]