大黄酚脂质体制备方法的研究  

Preparations of chrysophanol liposomes

作　　者：王立华[1] 王永利[1] 张江伟 李美红[1] 张丹参[3] 

机构地区：[1]河北北方学院应用化学研究所,张家口075000 [2]中国石油大学(北京)提高采收率研究院,北京102249 [3]河北北方学院基础医学院,张家口075000

出　　处：《中国新药杂志》2013年第12期1452-1454,共3页Chinese Journal of New Drugs

基　　金：河北省科学技术研究与发展计划(12276104D-94);河北北方学院自然科学青年基金(Q201112)

摘　　要：目的:旨在找出一种适合大黄酚脂质体的制备方法。方法:分别用手摇法、薄膜-超声法、乙醇注入法、乙醇注入-超声法等方法制备大黄酚脂质体,以包封率和渗漏率为评价指标,选出最适合大黄酚脂质体的制备方法。结果:薄膜-超声分散法制得的大黄酚脂质体平均包封率达(93.91±4.28)%,明显优于其他方法。结论:采用薄膜-超声法制备的大黄酚脂质体具有较高包封率和稳定性。Objective： To establish an appropriate method for preparing ehrysophano Chrysophanol liposomes were prepared by hand shaking, film-ultrasonic, ethanol injection, 1 liposomes. Methods： and ethanol injection- ultrasonic methods, respectively. The best technology was evaluated by regarding encapsulation efficiency and per-colation rate. Results： The chrysophanol liposomes prepared by the others, which showed an average entrapment effici somes prepared by film-ultrasonic dispersion method h ency of ave high （9 film-ultrasonic dispersion method was better than 3.91 ±4.28） %. Conclusion： Chrysophanol lipo- er entrapment efficiency and better stability

关 键 词：大黄酚 脂质体 包封率 渗透率 

分 类 号：R943.42[医药卫生—药剂学]