黄体期改良超长方案在子宫内膜异位症患者IVF中的应用  

Application of Luteal Phase Modified Super-long Protocol in IVF for Patients with Endometriosis

作　　者：廖月婵[1] 吴日然[1] 林晓丽[1] 吴嘉齐[1] 杜彦[1] 柯玩娜[1] 

机构地区：[1]广东省中山市博爱医院生殖中心,中山528403

出　　处：《生殖与避孕》2013年第6期402-404,F0003,共4页Reproduction and Contraception

摘　　要：目的:探讨改良后的黄体期超长方案降调节在子宫内膜异位症(EMs)和卵巢储备功能稍低患者行IVF治疗中的临床效果。方法:选取行IVF并确诊为EMs的患者112例,其中58例患者给予传统黄体期长效长方案降调节作为对照组,54例患者第1次降调节不理想后再次给予降调节者作为研究组,对比分析研究组和对照组患者的周期取消率、促性腺激素(Gn)使用量、Gn使用天数、获卵数、受精率、临床妊娠率、早期流产率及重度卵巢过度刺激综合征(OHSS)发生率。结果:研究组患者的临床妊娠率和受精率提高,周期取消率、流产率和重度OHSS发生率都有所降低。结论:改良黄体期长方案能够提高EMs患者的临床妊娠率和受精率,同时减少了周期取消率,是一种经济有效的降调节方案。Objective： To explore the clinical effect of modified super-long protocol of down-regulation in IVF treatment for patients with endometriosis （EMs） and low ovarian reserve. Methods： Confirmed 112 cases with EMs were collected, 58 patients received traditional super-long program and acted as the control, 54 patients had a non-ideal falling tone for the first time, then recieved the second demotion and attributed to the study group. The cancelled cycle rate, Gn dosage, days of Gn used, the number of oocytes retrieved, the fertilization rate, the clinical pregnancy rate, the early abortion rate and the number of severe OHSS occurred were compared between the two groups. Results： In the study group, the fertilization rate and the clinical pregnancy rate were increased, the cancelled cycle rate, the abortion rate and the severe OHSS incidence were reduced. Conclusion： The modil]ed long program can improve the clinical pregnancy rate of patients with EMs, while reducing the cycle concelled rate, and is a cost-el＇fective protocol of down-regulation.

关 键 词：改良黄体期超长方案 降调节 促排卵 子宫内膜异位症(EMs) IVF 

分 类 号：R711.71[医药卫生—妇产科学]