健康成人骨髓全身磁共振扩散加权成像研究  

Whole Body Diffusion-weighted MR Imaging Study of Bone Marrow in Healthy Adults

作　　者：徐贤[1] 马林[1] 安宁豫[1] 蔡幼铨[1] 刘新球[1] 

机构地区：[1]解放军总医院南楼放射科,北京100853

出　　处：《中国医学影像学杂志》2013年第6期401-405,410,共6页Chinese Journal of Medical Imaging

摘　　要：目的探讨健康成人骨髓全身磁共振扩散加权成像(WB-DWI)定量参数与性别、年龄、身高、体重、体重指数及性激素水平的相关性。资料与方法采用GE1.5T磁共振扫描仪对108名不同年龄组的健康成年受试者行WB-DWI扫描,并于扫描前后48h内测量其中60名受试者的雌二醇及孕酮水平。比较不同性别、不同年龄组骨髓表观扩散系数(ADC)值和信噪比(SNR)的差异。采用偏相关分析评价60名受试者骨骼系统ADC值和SNR与性别、年龄、身高、体重、体重指数、雌二醇及孕酮水平的相关性。结果女性受试者骨骼系统ADC值和SNR显著大于男性(P<0.01);不同年龄组骨骼系统ADC值和SNR有显著差异(P<0.01)。骨骼系统ADC值与年龄呈显著负相关(r=-0.642,P<0.01),与雌二醇、孕酮水平呈低正相关(r=0.278、0.271,P<0.05);SNR与年龄呈显著负相关(r=-0.709,P<0.01),与雌二醇水平呈低正相关(r=0.293,P<0.05);ADC值和SNR与身高、体重、体重指数均无明显相关性。结论骨骼系统ADC值和SNR受到性别、年龄和性激素水平的影响,不同性别、不同年龄健康成人骨骼系统WB-DWI表现存在差异。Purpose To explore the correlation between whole body magnetic resonance diffusion-weighted imaging （WB-DWI） quantitative parameters of healthy adults＇ bone marrow with gender, age, height, weight, body mass index, and sex hormone levels. Materials and Methods 108 healthy adult subjects in different age groups underwent WB-DWI scan using GE 1.5T MR scanner, among them estradiol and progesterone levels were measured in 60 subjects within 48 hours before or after the scan. Apparent dilthsion coefficient （ADC） values of bone marrow and the signal to noise ratio （SNR） were compared among different gender and age groups. Partial correlation analysis was used to evaluate the correlation of skeletal system ADC values and SNR with sex, age, height, weight, body mass index, estradiol and progesterone levels in 60 subjects. Results ADC values and SNR of the female subjects were significantly higher than males （P〈0.01）; there were significantly differences for skeletal system ADC values and SNR in different age groups （P〈0.01）. Skeletal system ADC values was significantly negatively correlated （r=- 0.642, P〈0.01） with age, and were mildly positively correlated （r=0.278, 0.271, P〈0.05） with estradiol and progesterone levels; SNR was significantly negatively correlated （r=-0.709, P〈0.01） with age, and was mildly positively correlated （r=-0.293, P〈0.05） with estradiol levels; ADC values and SNR had no significant correlation with height, weight and body mass index. Conclusion Skeletal system ADC values are effected by gender, age and sex hormone levels, the skeletal system WB-DWI manifestations are different in different gender and age groups.

关 键 词：骨髓 磁共振成像 弥散 扩散加权成像 表观扩散系数 成年人 

分 类 号：R445.2[医药卫生—影像医学与核医学]