登革病毒样颗粒疫苗的研究现状  

Review of study on Dengue virus-like particles vaccine

作　　者：付春云[1,2] 戴盛明[1] 周俊梅[2] 

机构地区：[1]广西医科大学第四附属医院检验科,广西柳州545005 [2]中山大学中山医学院微生物教研室,广东广州510080

出　　处：《基础医学与临床》2013年第7期927-930,共4页Basic and Clinical Medicine

摘　　要：登革病毒引起的疾病是一种严重威胁人类健康的蚊媒性急性传染病。但至今仍没有获批准的疫苗可用。近年,一种新的病毒样颗粒(VLPs)能使免疫小鼠产生中和性抗体和持久、特异的T淋巴免疫记忆细胞。VLPs克服了传统疫苗的很多不足,具有较大应用潜力。The infection caused by Dengue virus is an acute life-threatening mosquito-borne infectious disease. So far, an effective and safe vaccine for dengue is not yet available. Recently a new virus-like particles vaccine was developed which induces the vaccinated mice to produce neutralizing antibody, and long-lasting virus-specific mem- ory T lymphocytes. What more, it also can be widely explored by using yeast expression system. Its special priori- ties make it become a hopeful ideal dengue vaccine.

关 键 词：登革病毒 病毒样颗粒 疫苗 蚊媒性传染病 

分 类 号：R392.1[医药卫生—免疫学]