血小板平均体积与心肌桥的关系  

Relationship between mean platelet volume and myocardial bridging

作　　者：李珊珊[1] 陈馨[1] 张伟华[2] 陆林[1] 刘艳[1] 金玮[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院心内科,上海200025 [2]上海交通大学医学院附属瑞金医院放射科,上海200025

出　　处：《上海交通大学学报（医学版）》2013年第6期791-795,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81070177)~~

摘　　要：目的探讨血小板平均体积(MPV)变化与心肌桥(MB)的相关性。方法回顾性分析经冠状动脉造影确诊的孤立性MB患者(MB组,n=326)和冠状动脉造影正常者(对照组,n=334)的MPV差异。660例研究对象分别按性别和年龄分层,比较各亚组间MPV差异;多因素Logistic回归分析MB的危险因素。结果 MB组的MPV为(8.88±1.27)fl,高于对照组的(8.78±1.27)fl,但差异无统计学意义(P>0.05);相同性别组间MPV比较差异也无统计学意义(P>0.05)。选择灵敏度和特异度均较高的切点为最佳临界点,确定44岁为年龄划分的起始界值。按年龄分层后发现,在≤44岁年龄段,MB组的MPV为(9.49±1.30)fl,明显高于对照组的(8.62±1.31)fl,差异有统计学意义(P<0.01);在其他各年龄段,两组间MPV比较差异均无统计学意义(P>0.05)。分析≤44岁年龄段的临床资料,多因素回归分析显示MB与MPV有显著相关性(OR=1.71,95%CI 1.16～2.51,P<0.01),但与性别、血压、血脂均无相关性(P>0.05)。结论 MPV增加可能与MB有关,年轻MB患者中关联性更加显著。Objective To investigate the correlation between mean platelet volume （MPV） and myocardial bridging （MB）. Methods The data of MPV of patients with isolated MB confirmed by coronary angiography （MB group, u = 326） and those with normal coronary angiographic findings （control group, n = 334） were retrospectively analysed. All the study objectives were stratified by age and gender, and the differences in MPV were compared between subgroups. The risk factors of MB were explored by muhivariate Logistic regression analysis. Results There was no significant difference in MPV between MB group and control group [ （8.88± 1.27） fl vs （8.78 ± 1.27） fl, P 〉0.05], and there was also no significant difference in MPV between the same gender of two groups （P 〉 0.05）. The cutoff point of age was determined as 44 years with favorable sensitivity and specificity. In those aged no higher than 44 years, MPV in MB group was significantly higher than that in control group [ （9.49 ± 1.30） fl vs （8.62 ± 1.31） fl, P 〈 0.01 ], while there was no significant difference in MPV between two groups in the other age subgroups （P 〉 O. 05）. In those aged no higher than 44 years, multivariate regression analysis revealed that MB was significantly related to MPV （OR = 1.71, 95% CI 1.16 -2.51, P 〈 0.01）, while was not related to gender, blood pressure and blood lipid （P 〉 0.05）. Conclusion MB may be associated with the increase of MPV, and the relevance may be more significant in young patients with MB.

关 键 词：冠状动脉心肌桥 血小板平均体积 危险因素 

分 类 号：R541.1[医药卫生—心血管疾病]