自体移植静脉再狭窄基因水平的研究进展  

Stenosis of autogenous vein graft: processes at the gene level

作　　者：魏立春[1] 侯培勇[1] 李祺熠[1] 苏奕明[1] 郑毅[1] 

机构地区：[1]广西医科大学第四附属医院血管外科,广西柳州545005

出　　处：《中国普通外科杂志》2013年第6期766-770,共5页China Journal of General Surgery

摘　　要：为防治移植静脉再狭窄,基因水平的研究显然具有重要意义。笔者就近年来国内外针对移植静脉再狭窄的基因水平的探索进行综述,主要内容包括应用促血管再内皮化基因、抗血栓形成基因、抑制血管平滑肌细胞增殖和胞外基质沉积基因以及联合多基因共同治疗移植静脉再狭窄的研究,并指出未来基因水平研究发展方向。For prevention of the bypass vein graft stenosis, the gene-level investigations are obviously of great importance. This paper reviews the current literature regarding the gene-level investigations on vein graft stenosis, both at home and abroad. Its main focus is on the studies towards application of the genes involved in reendothelialization acceleration, anti-thrombosis, and inhibition of the vascular smooth muscle cell proliferation or extracellular matrix deposition, as well as multi-gene combination for vein graft restenosis. There is also a speculation on the direction of future development in this field.

关 键 词：移植物闭塞 血管 移植 自体 血管内膜增生 基因疗法 综述文献 

分 类 号：R654.4[医药卫生—外科学]