血浆血管紧张素转换酶活性与原发性高血压靶器官损伤的关系  

Relationship of serum anglotensin converting enzyme level and primary hypertension target organ damage

作　　者：张红艳[1] 张志涛[2] 

机构地区：[1]河北工程大学医学院检验系,邯郸056002 [2]邯郸市中心医院泌尿外二科

出　　处：《中国综合临床》2013年第7期708-710,共3页Clinical Medicine of China

基　　金：河北省科学技术研究与发展计划项目（11276103D-51）

摘　　要：目的探讨原发性高血压靶器官损伤与血浆血管紧张素转换酶（ACE）活性的关系。方法根据原发性高血压患者靶器官损伤情况将其分为原发性高血压并发冠心病组、并发脑梗死组和并发肾损伤组，每组60例；另选择60名健康成人设为正常对照组。检测各组的血浆ACE活性，并比较其差异。结果正常对照组，原发性高血压并发冠心病组、并发脑梗死组、并发肾损伤组血浆ACE活性分别为（21．36±6．86）、（36．09±4．87）、（39．15±7．03）、（28．34±7．23）U／L，组间比较差异有统计学意义（F=343．997，P〈0．01），且各并发症组均比正常对照组高（P均〈O．01），在各并发症组中并发肾损伤组血浆ACE活性最低。结论原发性高血压靶器官损伤的发生与高活性的ACE有关，而且高活性的ACE最容易引起肾脏损伤。Objective To investigate the relationship of serum angiotensin converting enzyme （ACE） level and primary hypertension target organ damage. Methods According to target organ damage , essential hypertension patients were divided into 3 groups： primary hypertension with coronary artery disease, primary hypertension with cerebral infarction and primary hypertension with kidney injury. There were 60 subjects in each complication group. There were 60 healthy adults in the normal control group. Serum ACE level was detected and compare among the 4 groups. Results Serum ACE level in normal control group was （21.36 ± 6. 86） U/L, while that in primary hypertension with coronary artery disease, primary hypertension with cerebral infarction and primary hypertension with kidney injury were （36.09 ±4. 87） U/L, （39. 15 ±7.03） U/L and （28. 34 ±7.23） U/L respectively. Serum ACE level was higher in each complication group than in normal control group （ F = 343. 997, P 〈 0. 01 ）. In the complication groups, serum ACE level was the lowest in the group of primary hypertension with kidney injury. Conclusion High active ACE is associated with target organ damage in primary hypertension , especially kidney injury.

关 键 词：原发性高血压 靶器官损伤 血管紧张素转换酶 血管紧张素转换酶活性 

分 类 号：R544.1[医药卫生—心血管疾病]