盐酸曲马多注射液与盐酸布比卡因注射液在镇痛泵中的稳定性研究  

Stability and compatibility of tramadol hydrochloride with bupivacaine hydrochloride in analgesia pump

作　　者：张滔[1] 方宝霞[1] 陈富超[1] 朱军[1] 李鹏[1] 

机构地区：[1]湖北医药学院附属东风医院药学部 ,湖北省十堰市442008

出　　处：《中国医药》2013年第7期1011-1012,共2页China Medicine

摘　　要：目的考察盐酸曲马多注射液与盐酸布比卡因注射液在镇痛泵中的稳定性。方法采用高效液相色谱（HPLC）法测定配伍液中盐酸曲马多与盐酸布比卡因在72h内的含量变化，并观察和检测配伍液的外观及pH值变化。结果盐酸曲马多注射液与盐酸布比卡因注射液在0．9％氯化钠注射液中配伍后，在室温条件下放置72h，盐酸曲马多与盐酸布比卡因的加样回收率分别为99．48％、100．20％，且配伍液无色澄明，pH无明显变化，两者的含量均〉98％，分别为100．16％和98．68％。结论在室温条件下，盐酸曲马多注射液与盐酸布比卡因注射液在镇痛泵中72h内均保持稳定。Objective To study the stability of tramadol hydrochloride injection with bupivacaine hydro- chloride injection in analgesia pump. Methods With high pressure liquid chromatography, the content of tramadol hydroetdoride and bupivacaine hydrochloride in mixture solution at 72 hours were determined; the appearance of the mixture solution was observed and its pH value was determined. Results There were no significantly Changes in the appearance, pH values and contents of tramadol hydrochloride and bupivacairie hydrochloride of the mixture solution within 72 hours at room temperature. The recoveries were 99.48% and 100.20% ; the contents were 100. 16% and 98.68% , respectively. Conclusion The mixture of trarnadol hydroehloride with bupivacaine hydrochloride in anal- gesia pump is stable within 72 hours under room temperature.

关 键 词：盐酸曲马多 盐酸布比卡因 配伍 稳定性 高效液相色谱法 

分 类 号：R927[医药卫生—药学]