T细胞亚群变化与慢性重型病毒性肝炎转归关系分析  

Analysis of changes of T cell subsets and chronic severe hepatitis prognosis

作　　者：李健[1] 邹文娟[2] 梅小平[1] 

机构地区：[1]川北医学院附属医院传染科,四川南充637000 [2]重庆市中医院肿瘤科,400021

出　　处：《重庆医学》2013年第18期2090-2092,共3页Chongqing medicine

摘　　要：目的探讨慢性重型乙型肝炎(CSHB)患者外周血T细胞亚群变化与预后的关系。方法采用流式细胞仪分别检测符合条件的CSHB、慢性乙型肝炎(CHB)、健康对照者的外周血T细胞亚群、血生化、凝血酶原活动度。治疗后,根据病情变化将CSHB分为好转组和无好转组。对治疗前、后各组检测结果进行数据分析和统计学处理。结果治疗前,CD3、CD4+T细胞、CD8+T细胞、CD4+/CD8+比值:CSHB组与CHB组、对照组比较均有明显下降,差异有统计学意义(P<0.01),CHB组与对照组比较差异无统计学意义(P>0.05)。治疗后,CSHB无好转组CD3、CD4+T细胞、CD8+T细胞进一步下降、CD4+/CD8+比值上升,好转组CD3、CD4+T细胞、CD4+/CD8+比值上升,CD8+T细胞下降。CD3、CD4+T细胞、CD8+T细胞、CD4+/CD8+比值:无好转组与好转组、CHB组、对照组之间比较差异有统计学意义(P<0.01);CHB组与对照组比较差异无统计学意义(P>0.05)。结论 CSHB患者外周血T细胞亚群变化趋势对CSHB的诊断及判断预后有重要的指导意义。Objective To investigate the relationship between the changes and the prognosis of T lymphocyte subsets in patients′ peripheral blood with Chronic severe hepatitis B（CSHB）.Methods T cell subsets in peripheral blood（by flow cytometry）、 blood biochemistry and prothrombin activity,in patients with CSHB or CHB as well as in the healthy control group.After treatments,according to the illness change,the patients with Chronic severe hepatitis B（CSHB）were divided into improvement group and no improvement group.Do data analysis and statistics of test results before and after treatments.Results Before the results of treatment,compared with the patients with CHB and the healthy control group,the counts of T lymphocyte subsets CD3,CD4＋T cell,CD8＋T cell,CD4/CD8＋ ratio in the patients with CSHB decreased significantly,a statistically significant difference（P＆lt;0.01）,while the difference in the patients with CHB and in the control group was not statistically significant（P＆gt;0.05）.After treatment,the counts of CD3,CD4＋T cell,CD8＋T cell in patients with（CSHB） in no improvement group declined further：the CD4＋/CD8＋ ratio rised.While in the improvement group,the CD3,CD4＋T cells and the CD4＋/CD8＋ ratio rised：the CD8＋Tcells declined.The difference of CD3,CD4＋T cells,CD8＋Tcells,the CD4＋/CD8＋ ratio between the improvement group and no improvement group,chronic hepatitis B group as well as the healthy control group was statistically significant（P＆lt;0.01）：there was no statistically significant difference between chronic hepatitis B group and the control group.Conclusion The trends of peripheral blood T-cell subsets in patients with CSHB are of important significance to diagnosis and prognosis.

关 键 词：肝炎 乙型 慢性 T淋巴细胞亚群 预后 

分 类 号：R512.6[医药卫生—内科学]