脂质体型奥沙利铂经动脉灌注给药对兔VX_2肝移植瘤的影响  

Effects of liposomal oxaliplatin by intra-arterial infusion on VX_2 liver xenografts in rabbits

作　　者：赵保成 冯耀良 辛洪亮[2] 施海彬 徐群为[2] 祖庆泉 周卫忠 

机构地区：[1]南京医科大学第一附属医院介入放射科,江苏省210029 [2]南京医科大学药学院

出　　处：《江苏医药》2013年第12期1391-1394,共4页Jiangsu Medical Journal

摘　　要：目的探讨脂质体型奥沙利铂经动脉灌注给药对兔VX2肝移植瘤的影响。方法 25只兔VX2肝移植瘤模型建立14d后均分为五组:空白对照(A)组;游离型奥沙利铂静脉注射(B)组和动脉灌注(C)组;脂质体型奥沙利铂静脉注射(D)组和动脉灌注(E)组。均一次性给予奥沙利铂10mg/kg。用高效液相色谱法检测给药后2、24、48h肿瘤组织中奥沙利铂浓度;CT扫描计算治疗前1d、治疗后7d肿瘤体积、增长体积及增长率;检测各组治疗前1d及治疗后1、3、7d肝肾功能。结果 25只兔VX2肝移植瘤模型均成功建立。E组移植瘤奥沙利铂浓度显著高于其他各组(P<0.05)。治疗后7d,五组肿瘤体积均较治疗前增大;但E组肿瘤体积、增长体积及增长率均小于其他各组(P<0.05)。治疗后1、3d,B、C、D、E组ALT、AST、BUN、Cr值均升高(P<0.05),治疗后7d,各组肝肾功能均恢复至治疗前水平。结论脂质体型奥沙利铂经动脉灌注治疗兔VX2肝移植瘤有效、安全。Objective To explore the effects of liposomal oxaliplatin by intra-arterial infusion on VXz liver xenografts in rabbits. Methods VXz liver xenografts models were established in 25 rabbits. Fourteen days later, 25 rabbits were equally divided into five groups of A（blank controls）, B （free oxaliplatin infused intravenously）, C （ free oxaliplatin infused intraarterially）, D （ liposomal oxaliplatin infused intravenously） and E （liposomal oxaliplatin infused intraarterially）. Oxaliplatin 10 mg/kg for one time was given in groups of B, C, D and E. Drug concentration in xenografts was detected by high performance liquid chromatography at 2,24 and 48 hours after administration. The volumes of xenografts, increased volumes, and growth rates were evaluated by CT scan one day before and on the 7th day after treatment. Liver and renal functions were examined one day before and on the Ist, 3rd and 7th day after treatment. Results VXz liver xenografts models were all successfully established. Drug concentration in group E was significantly higher than that in other groups （P〈0. 05）. Tumor volumes in five groups were all enlarged on the 7th day after treatment. But the tumor volume, increased volume and growth rate were lower in group E than those in other 4 groups on the 7th day after treatment （P〈0. 05）. The levels of ALT, AST, BUN, and Cr were higher in groups of B,C,D and E on the 1st, 3rd day after treatment（P〈0. 05）, but which returned to normal level on the 7th day after treatment. Conclusion Intraarterial administration of liposomal oxaliplatin in treating VXz liver xenografts is effective, feasible and safe.

关 键 词：VX2肝移植瘤 脂质体奥沙利铂 

分 类 号：R730[医药卫生—肿瘤]