高通量血液透析和阿法骨化醇冲击治疗对血液透析患者继发性甲状旁腺功能亢进的疗效研究  

Effects of high-flux hemodialysis and pulse alfacalcidol on secondary hyperparathyroidism of hemodialysis patients

作　　者：包国豪[1] 陈法东[1] 张疆[1] 黄艳[1] 陈建胜 缪初升[1] 

机构地区：[1]温州医学院附属第三医院肾内科,浙江瑞安325200 [2]瑞安市中医院肾内科,浙江瑞安325200

出　　处：《实用药物与临床》2013年第6期480-482,共3页Practical Pharmacy and Clinical Remedies

基　　金：浙江省温州市科技局计划项目(Y20090432)

摘　　要：目的观察高通量血液透析和阿法骨化醇冲击治疗维持性血透患者继发性甲状旁腺功能亢进(SHPT)的疗效及其对钙、磷水平的影响。方法将115例维持性血透患者随机分为高通量血液透析(HFHD)组(50例)和阿法骨化醇冲击治疗组(65例),比较两组治疗前后的iPTH、血钙及血磷水平变化。结果①两组患者的iPTH水平均明显下降(P<0.01),其中HFHD组下降幅度较大,差异有统计学意义(P<0.01)。②两组患者血钙水平较治疗前有上升趋势,但差异无统计学意义(P>0.05)。③HFHD组患者血磷水平有下降趋势,差异有统计学意义(P<0.05)。结论高通量血液透析和阿法骨化醇冲击治疗对血液透析患者继发性甲状旁腺功能亢进有明显的效果。Objective To observe the effects of high-flux hemodialysis （HFHD）and pulse alfacalcidol therapy on secondary hyperparathyroidism and serum calcium and phosphorus levels in maintenance hemodialysis patients. Methods 115 cases of maintenance hemodialysis patients were randomly divided into two groups：HFHD group （n = 50） and pulse alfacalcidol group （n = 65 ）. Levels of serum iPTH, calcium and phosphorus were compared before and after treatment. Results ①The iPTH levels of the two groups decreased significantly （ P 〈 0.01 ）, and there was signif-icant difference between the two groups （ P 〈 0.05 ）. ②The serum Ca levels of the two groups had a rising trend, but no significant difference was observed（ P 〉 0. 05 ）. ③The serum phosphorus levels of the HFHD group had a downward trend（ P 〈 0. 05 ）. Conclusion Both HFHD and pulse alfacalcidol treatment have obvious effects on secondary hyper-parathyroidism in hemodialysis patients.

关 键 词：肾透析 甲状旁腺功能亢进症 阿法骨化醇 冲击治疗 高通量血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]