内标法测定奥扎格雷钠颗粒的含量  

Determination of ozagrel sodium granules by internal standard method

作　　者：张勇[1] 陈玉威[1] 高桂花[2] 

机构地区：[1]辽宁省药物研究院,沈阳110015 [2]济宁医学院药学院,山东日照276826

出　　处：《实用药物与临床》2013年第6期517-519,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的建立内标法测定奥扎格雷钠颗粒含量。方法采用C18柱,以0.02 mol/L乙酸铵溶液-甲醇(75∶25)为流动相,流速:1.0 mL/min,柱温:25℃,检测波长:276 nm。结果浓度在0.028～0.066 mg/mL范围内具有良好的线性关系(r=0.999 9),平均回收率为99.37%,RSD为0.92%(n=9),精密度RSD为1.07%(n=6)。结论该方法简便、快速、专属性强,能满足制剂质量标准的要求。Objective To establish a method to determine ozagrel sodium granules by internal standard method.Methods The analysis w as conducted w ith C18 column,and the column temperature w as 25 ℃,the mobile phase consisted of 0.02 mol / L ammonium acetate solution-methanol（75∶ 25） w ith the flow rate of 1.0 mL / min,the detection w avelength w as at 276 nm.Results A good linear relationship existed in 0.028 ～ 0.066 mg / mL（r = 0.999 9）,the average recovery rate w as 99.73%,RSD = 0.92%（n = 9）,the RSD of precision w as 1.07%（n = 6）.Conclusion The method is simple,rapid,highly specific and can meet the requirements of the standard of quality of the preparations.

关 键 词：奥扎格雷钠 内标法 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学]