不同糖代谢人群血清SAA、CRP的变化研究  

Level Change of Serum Amyloid A and C-Reactive Protein in Different Glucose Metabolism Groups

作　　者：牛玲[1] 张建伟[1] 罗平[1] 李博一[1] 饶迪[1] 唐树荣[1] 胡大春[1] 唐艳[1] 

机构地区：[1]昆明市第一人民医院内分泌科,云南昆明650031

出　　处：《昆明医科大学学报》2013年第5期107-109,120,共4页Journal of Kunming Medical University

基　　金：昆明市第一人民医院院内基金资助项目(2008kjc05)

摘　　要：目的探讨不同糖代谢人群血清SAA、CRP的水平.方法检测糖尿病前期(糖调节受损)以及初诊2型糖尿病患者血清SAA、CRP水平并比较其相关性.结果 (1)IGR组、DM组SAA、CRP水平较正常对照组增加,差异有统计学意义(P<0.05);(2)DM组与IGR组比较,SAA、CRP升高,差异有统计学意义(P<0.05);(3)SAA与CRP呈正相关(r=0.516).结论糖调节受损人群,初诊2型糖尿病患者血清炎症因子水平升高,SAA,CRP均可作为糖代谢紊乱人群有用的预测因子.Objective To investigate the level of serum amyloid A （SAA） and C-reactive protein （CRP） in cases with different glucose metabolism. Methods The level of serum SAA and CRP of the patients with impaired glucose regulation （ICR） and type 2 diabetes mellitus （DM） was detected and compared. Results The SAA and CRP level of IGR and DM was obvious higher than that of normal control group （P 〈 0.05） There was a significant difference of SAA and CRP between DM and ICR （P 〈 0.05） . The SAA level of inflammatory eytokines had a positive correlation with CRP. Conclusion The level of inflammatory cytokines is higher in IGR and T2DM, and both SAA and CRP can be used as useful predictors of glucose metabolism disorders.

关 键 词：血清淀粉样蛋白 C反应蛋白 糖调节受损 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]