血流储备分数评价糖尿病患者冠脉临界病变可靠性的研究  

Clinical studies on the reliability of fractional flow reserve measurement in assessing the marginal stenosis of coronary artery in patients with diabetes mellitus

作　　者：范书霞[1] 韩战营[1] 邱春光[1] 陈晓杰[1] 卢文杰[1] 

机构地区：[1]郑州大学第一附属医院心血管内科,河南郑州450052

出　　处：《河南医学研究》2013年第3期324-326,共3页Henan Medical Research

摘　　要：目的:探讨糖尿病对心肌血流储备分数(FFR)的影响,评价FFR指导糖尿病患者冠状动脉临界病变介入治疗的可靠性。方法:入选经定量冠状动脉造影示临界病变(狭窄40%～70%)且进行FFR测量的糖尿病患者21例,非糖尿病患者36例。依据管腔狭窄程度(40%～50%,51%～60%,61%～70%)进行分组,比较每组中糖尿病患者和非糖尿病患者FFR值的差异。结果:糖尿病患者临界病变共37处,非糖尿病患者临界病变共57处。冠状动脉狭窄程度相似时,糖尿病组和非糖尿病组的FFR值无统计学差异(P>0.05)。结论:糖尿病微血管病变对FFR值无显著影响,FFR指导糖尿病患者临界病变的介入治疗是可靠的。Objective ： To investigate the effect of diabetes on fractional flow reserve （ FFR ） values, and assess the reliability of FFR measurement in guiding the interventional therapy in diabetic patients with coronary marginal lesions. Methods： Fifty-seven patients with coronary marginal lesions who undergone FFR measurement were enrolled in our study. The patients were divided according to the degree of the luminal narrowing（stenosis 40% - 50% ,51% - 60% ,61% - 70% ）. Then the FFR values of the patients with and without diabetes were compared in each category. Results：There were thirty-seven marginal lesions in diabetic groups, and fifty-seven lesions in non-diabetic patients. There was no significance between the FFR values of diabetic patients and non-diabetic patients who had similar degree of stenosis. Conclusion ： The disfunctional microvessels in diabetic patients does not have a significant impact on FFR values and FFR is reliable to guide the interventional therapy in diabetic patients with marginal stenosis.

关 键 词：血流储备分数 临界病变 糖尿病 定量冠状动脉造影 

分 类 号：R587.1[医药卫生—内分泌]