气固相催化法合成N-乙基哌嗪的研究  

Study on synthesis of N-ethylpiperazine by gas-solid phase catalytic

作　　者：兰婷[1] 李穆琼[1] 李明华[1] 高鹏[1] 张俊娜[1] 苏海鹏[2] 王宝龙[1] 

机构地区：[1]第四军医大学药学院,陕西西安710032 [2]西安近代化学研究所,陕西西安710065

出　　处：《应用化工》2013年第6期990-991,共2页Applied Chemical Industry

基　　金：国家自然科学基金项目资助(21202202)

摘　　要：以哌嗪和乙醇为原料,采用气固相催化法合成N-乙基哌嗪,考察了哌嗪浓度、流量、温度和压力对哌嗪转化率、N-乙基哌嗪和三乙烯二胺选择性的影响。结果表明,哌嗪浓度为30%,温度280℃,反应液流率1.5 mL/min,氢气压力为0.6 MPa时反应结果较好。The synthesis of N-ethylpiperazine by gas-solid phase catalytic, using piperazine and ethanol as raw material. The influence of the concentration of piperazine and flow rate, temperature and pressure on the conversion rate of piperazine, the selectivity of N-ethylpiperazine and triethylenediamine was investiga- ted. Results shows that the reaction had a better selectivity in condition of piperazine concentration 30%, temperature 280 ~C, liquid flow rate 1.5 mL/min, hydrogen pressure 0.6 MPa.

关 键 词：哌嗪 N-乙基哌嗪 气固相催化 

分 类 号：TQ463.5[化学工程—制药化工]