慢性肾脏病患者不同时期血清CysC和GGT水平的探讨  

The Serum Levels of Cystatin C and Glutamyl Transferase in Different Stages of Chronic Kidney Disease

作　　者：刘继勇[1] 钱成荣[1] 王建军[1] 丁俊丽[1] 赵勇[1] 周志伟[1] 银广悦[1] 

机构地区：[1]中国石油天然气集团公司中心医院检验科,河北廊坊065000

出　　处：《标记免疫分析与临床》2013年第3期148-150,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨慢性肾脏疾病(CKD)患者血清半胱氨酸蛋白酶抑制剂C(CysC)和谷氨酰转移酶(GGT)含量及两者相关性。方法根据K/DOQI临床分期将研究对象分为5组,CKDⅠ期组36例,CKDⅡ期组39例,CKDⅢ期组36例,CKDⅣ期组20例,CKDⅤ期组24例,对照组45例,对各组患者及正常对照组进行血清CysC、GGT及肌酐(Cr)水平检测。结果CKD患者各期的血清CysC及GGT含量明显高于正常对照组(P<0.01);血清GGT在CKD各期之间无统计学意义(P>0.05);Cys-C与Cr水平随肾损伤的严重程度而升高,且Cys C与Cr呈正相关(r=0.9980)。结论血清Cys-C是评价早期肾小球滤过功能灵敏指标,也是判断肾损伤程度和疗效观察有价值检测指标之一。Objective To explore the correlation between serum levels of Cystatin C and Glutamyl transferase（GGT） in patients with chronic kidney disease（CKD）.Methods Patients with chronic kidney disease were divided into CKD stage 1（36cases）,CKD stage 2（39 cases）,CKD stage 3（36cases）,CKD stage 4（20 cases） and CKD stage 5（24 cases） groups according to K/DOQI.The serum levels of CysC,GGT and Cr in each group and 45 healthy people（control group） were detected.Results The serum levels of CysC and GGT in patients were significantly higher that of control group（P0.01）.There was no significantly difference in patients for serum GGT levels at different stages（P0.05）.The serum CysC and Cr levels were increased as the kidney lesion become worse,and there was a positive correlation between the serum Cys C and Cr（r=0.9980）.Conclusion The serum CysC is a sensitive indicator for early glomerular filtration faction,and might be a very valuable in assessing the kidney lesion stage and monitoring therapy effects.

关 键 词：胱抑素C 谷氨酰转移酶 肌酐 肾小球滤过率 慢性肾脏疾病 

分 类 号：R692[医药卫生—泌尿科学]