13452例HPV亚型感染检测结果分析  

Detection of Human Genotype Papilloma Virus Infection in 13452 Cases

作　　者：魏葆珺[1] 李学祥[1] 齐军[1] 

机构地区：[1]中国医学科学院肿瘤医院肿瘤研究所检验科,北京100021

出　　处：《标记免疫分析与临床》2013年第3期169-171,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的通过对13452例人乳头瘤病毒(HPV)亚型感染检测结果的分析,了解检测样本的HPV感染状况及年龄分布特点。方法采用导流杂交技术检测21种HPV亚型,包括14种高危型和7种低危型HPV,分析受检妇女中常见的HPV亚型感染及分布规律。结果 HPV亚型感染总阳性率为36.98%,21种亚型被检出。高危型以HPV16最为常见,低危型最常见为HPV53。HPV多重感染比例为24.08%,以二重感染最为多见。结论 13452例受检妇女HPV亚型感染总阳性率为36.98%,常见的3种高危型为HPV16、HPV58、HPV52,2种低危型为HPV53和HPVcp8304。19～29岁年龄组,≥60岁年龄组的HPV亚型感染阳性率和HPV多重感染阳性率表现出较弱的高峰,HPV多重感染以二重感染最多见。Objective To evaluate the genotype and age distribution of human genotype papilloma virus（HPV） infection in 13452 cases.Methods The 21 different genotypes including 14 high-risk genotypes and 7 low-risk genotypes of HPV in 13452 cases were detected by flow through tybridization.Results The total positive rate of HPV infection was 36.98%.All 21 different genotypes were found.The most common high-risk genotype and low-risk genotype was HPV16 and HPV53,respectively.The multiple infection rate was 24.08% and two co-infections were the most common situation.Conclusion The 3 most common high-risk genotypes of HPV infection are HPV16,58,52,and the 2 most common low-risk are HPV53 and cp8304.The infection peak age is 19 to 29 years old and ≥60 years old.Two types co-infection are the most common multiple HPV infection.

关 键 词：人乳头瘤病毒 亚型 导流杂交 宫颈病变 

分 类 号：R373[医药卫生—病原生物学] R737.33[医药卫生—基础医学]