AFP和CEA在两种化学发光免疫分析系统的比对研究  

Comparison of AFP and CEA Detection Between Two Different Chemiluminescence Immunoassay Systems

作　　者：任曲[1] 李沛轩[1] 王红[1] 

机构地区：[1]北京空军总医院临床检验中心,北京100142

出　　处：《标记免疫分析与临床》2013年第3期182-184,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨不同化学发光检测系统测定甲胎蛋白(AFP)和癌胚抗原(CEA)结果的可比性,为本实验室不同检测系统检验结果的一致性提供依据。方法分别在西门子ADVIA Centaur XP和国产北京滨松BHP9504两种化学发光免疫分析系统测定AFP和CEA,依据美国临床实验室标准化协会(CLSI)EP9-A2文件的规定,以西门子ADVIA Centaur XP为比较方法,以国产北京滨松BHP9504为实验方法,进行方法学比对试验。结果两种系统各项结果间均呈良好的线性关系,其相关系数r均大于0.99,预期偏倚和相对偏倚均小于可接受限。结论两种化学发光免疫分析系统比对结果可以被临床接受。Objective To explore the comparability of alpha fetoprotein（AFP） and carcinoembryonic antigen（CEA） detection results and provide basis for result concordance in different chemiluminescence immunoassay systems.Methods Referring to the document of NCCLS EP9-A2,the testing Results derived from two analysis systems were analyzed comparatively and their biases was evaluated by analysis in SIEMENS ADVIA Centaur XP as a control method and analysis in BHP9504 as experimental method.Results The testing results of AFP and CEA by two different systems were linear correlation（r0.99）.Their anticipated biases were within accepted biases.Conclusion The test results of AFP and CEA by two different systems could be accepted by clinic.

关 键 词：EP9-A2 AFP CEA 比对研究 化学发光免疫分析法 

分 类 号：R446.6[医药卫生—诊断学]