通腑消胀方治疗肿瘤患者服用吗啡类药物所致便秘的临床研究  

Clinical Research of Tongfu Xiaozhang Prescription in the Treatment of Constipation Caused by Morphine Drugs

作　　者：张雅月[1] 黄佳琴[1] 侯丽[1] 李忠[1] 陈信义[1] 

机构地区：[1]北京中医药大学东直门医院血液肿瘤科,北京100700

出　　处：《中医学报》2013年第7期932-934,共3页Acta Chinese Medicine

基　　金：北京中医药大学资助选题项目(编号:2009CB522705)

摘　　要：目的:观察通腑消胀方对应用吗啡类药物所致便秘的肿瘤患者排便情况的改善作用。方法:将61例患者按随机数字表单盲法分为治疗组33例和对照组28例。对照组口服麻仁润肠软胶囊,每次8粒,每天早晚餐后30 min服用。治疗组口服通腑消胀方(生黄芪30 g,焦槟榔12 g,莱菔子15 g,商陆6 g)治疗,每日1剂,水煎取液300 mL,早晚分服。两组患者分别于治疗前,治疗第7天、第14天,停药第7天时观察排便积分变化情况并分析通便疗效。结果:治疗组和对照组在3个监测时间点的排便积分与治疗前比较,差异均有统计学意义(P<0.01);治疗组第14天排便积分与对照组治疗后比较,差异有统计学意义(P<0.05)。两组疗效比较,治疗组在治疗第7天、第14天与对照组比较,差异均有统计学意义(P<0.05);停药后第7天,与对照组比较,差异无统计学意义(P>0.05))。结论:通腑消胀方能够降低肿瘤患者因服用吗啡类药物所致便秘的排便积分,提高排便疗效。Objective：To observe the effect of Tongfuxiaozhang prescription in the treatment of constipation caused by morphine drugs.Methods：61 patients were randomly divided into treatment group（n=33）and control group（n=28）cases.The control group was given oral Maren Runchang soft capsule,8 capsules each time,taking in 30 min after breakfast and dinner.The treatment group was given oral Tongfu Xiaozhang prescription,1 agent daily,water fry 300 mL,sooner or later.Observe the defecation integrals and purgation effect before treatment,treatment for seventh days,fourteenth days and after stop drug seventh days.Results：Compared the defecation score before treatment in the 3 monitoring points,the difference was statistically significant（P0.01）.Compared the defecation score in fourteenth days with control group after treatment,the difference was statistically significant（P0.05）.Compared the effect in treatment group in the seventh days,fourteenth days with control group,the difference was statistically significant（P0.05）.But in seventh days after treatment,the difference was not statistically significant（P0.05））.Conclusion：Tongfuxiaozhang prescription can reduce the the defecation score in cancer patients caused by morphine and improve the defaecation effect.

关 键 词：便秘 通腑消胀方 吗啡 麻仁润肠软胶囊 

分 类 号：R256.35[医药卫生—中医内科学]