银杏达莫注射液联合羟苯磺酸钙治疗慢性肾衰竭的临床研究  

Efficacy of Gingko damo combined with calcium dobesilate for the treatment of chronic renal failure

作　　者：宋富玲[1] 赵雪梅 肖爱国 李晓菊 于荣 周旭东 孙东[1,3] 

机构地区：[1]徐州医学院内科学和诊断学教研室,江苏徐州221002 [2]伊犁哈萨克自治州奎屯医院检验科,新疆奎屯833200 [3]伊犁哈萨克自治州奎屯医院消.肾内科

出　　处：《徐州医学院学报》2013年第5期296-298,共3页Acta Academiae Medicinae Xuzhou

基　　金：基金项目：国家自然科学基金（81270769）;新疆伊犁哈萨克自治州奎屯市课题（201134）;江苏省医学重点人才项目（RC2011116）;江苏省第七批“六大人才高峰”资助项目（2010-ws043）;江苏省青蓝工程资助项目（53051106）;徐州市科技发展基金（XF10C076）;徐州医学院院长专项基金（2010KJZ23）

摘　　要：目的观察银杏达莫注射液联合羟苯磺酸钙治疗慢性肾衰竭（CRF）的临床疗效。方法120例CRF患者应用随机数字表法随机分为羟苯磺酸钙组、银杏达莫组、联合用药组（每组n=40）。3组均给予一定的基础治疗，在此基础上羟苯磺酸钙组给予羟苯磺酸钙0．5g每日3次口服；银杏达莫组给予银杏达莫注射液20ml静脉输注，每日1次；联合用药组给予银杏达莫联合羟苯磺酸钙治疗，疗程均为14天。分别于用药前及用药后第14天测定患者血肌酐（SCr）、尿素氮（BUN）、视黄醇结合蛋白（RBP）、24小时尿蛋白定量（24h—UP）、三酰甘油（TG）、血清总胆固醇（CHOL）水平。结果3组治疗后SCr、CHOL、TG、24h～UP水平均较治疗前明显降低（P〈0．05），BUN、RBP降低不明显（P〉0．05）。与其他2组比较，联合用药组治疗后SCr、CHOL、TG、24h—UP水平明显降低（P〈0．05），羟苯磺酸钙组与银杏达莫组之间治疗后各指标差异无统计学意义（P〉0．05）。结论银杏达莫注射液联合羟苯磺酸钙治疗CRF显著降低患者的SCr、CHOL、TG、24h—UP水平，疗效优于单用银杏达莫注射液或羟苯磺酸钙。Objective To investigate the therapeutic effects of Gingko damo combined with calcium dobesilate on chronic renal failure （CRF）. Methods 120 patients with CRF were randomly divided into calcium dobesilate group, Gingko damo group and combined treatment group using random number table （n = 40 each）. Patients in all the three groups received the same basic treatment. In addition, calcium dobesilate group were treated with calcium dobesilate, 0. 5 g orally tid; Gingko damo group were treated with Gingko damo injection, 20 ml intravenous infusion qd; combined treatment group were treated with both intravenous infusion of Gingko damo and oral administration of calcium dobesilate. The course of treatment was 14 days in each group. The levels of serum creatinine （SCr）, retinol - binding protein （RBP） , urea nitrogen （BUN） , total cholesterol （CHOL） , triglyceride （TG） , and 24 - hour urine protein （24h - UP） were observed before treatment and at 14th day after drug therapy. Results The levels of SCr, CHOL, TG, and 24h - UP were reduced significantly after the treatment in all the 3 groups （ P 〈 0.05 ）, but the levels of BUN and RBP were not reduced obviously （P 〉 0.05）. Compared with the other two groups, the levels of SCr, CHOL, TG, and 24h - UP in combined treatment group were significantly decreased （ P 〈 0.05 ）, while there was no obvious difference between Gingko damo group and calcium dobesilate group （P 〉 0.05）. Conclusion Gingko damo combined with calcium dobesilate for the treatment of CRF can decrease the SCr, CHOL, TG, and 24h - UP levels markedly, which is more effective than the Gingko damo or calcium dobesilate alone.

关 键 词：慢性肾衰竭 银杏达莫 羟苯磺酸钙 

分 类 号：R692.6[医药卫生—泌尿科学]