氨基磺酸催化绿色合成3，4-二氢嘧啶-2-酮  

Green synthesis of 3, 4 -dihydropyrimidin- 2 -ones catalyzed by sulfamic acid

作　　者：王倩[1] 贺玲[1] 刁晓菊[1] 田璐[1] 於露[1] 

机构地区：[1]徐州医学院生化与化学教学实验中心,江苏徐州221004

出　　处：《徐州医学院学报》2013年第6期368-371,共4页Acta Academiae Medicinae Xuzhou

基　　金：基金项目：江苏省高校自然科学基金（10KJB150018）;徐州医学院院长专项基金（2010KJZ20）;江苏省有机合成重点实验室开放课题（KJS1010）

摘　　要：目的使用氨基磺酸（H2NSO3H,SA）为催化剂，在水相中绿色合成一系列新的Biginelli反应产物——3，4-二氢嘧啶-2-酮类化合物。方法以醛、酮酯和尿素为原料，SA为催化剂，微波辐射，水相中合成目标化合物。结果反应8～17min完成，产率81％-92％，所有产物均通过熔点、红外光谱和氢核磁共振谱等表征检测确认结构。结论提供了一种氨基磺酸催化，水相中清洁合成二氢嘧啶酮的方法。催化剂使用方便、经济，环境友好。： Objective To develop a method of green synthesis of the title compounds, 3, 4 - dihydripyrimidin - 2 -ones in aqueous media using sulfamic acid （H2NSO3 H, SA） as catalyst for the Biginelli reaction. Methods The target compounds were synthesized via one - pot three components reactions by the mixture of aldehyde, keto esters and urea in water and under microwave irradiation in the presence of a catalytic amount of H2 NSO3 H. Results The reactions were completed in 8 - 17 rain with yields of 81% - 92%. The structures of the products were determined by M. P. , IR and 1H NMR spectra. Conclusion The use of SA as a catalyst for the green synthesis of 3, 4 - dihydropyrimidin - 2 - ones makes the process convenient, economical and environmentally friendly.

关 键 词：3 4-二氢嘧啶-2-酮 氨基磺酸 绿色合成 

分 类 号：R313[医药卫生—基础医学]