TGF-β家族信号的细胞内传导蛋白:SMAD蛋白家族  

Intracellular Signaling Proteins of TGF-β:SMAD Proteins Family

作　　者：刘一平[1] 邓继先[1] 黄翠芬[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物工程进展》2000年第3期8-12,共5页Progress in Biotechnology

摘　　要：SMADs是新近发现的参与TGF β超家族的信号在细胞内传导的一族蛋白 ,包括 8个成员 ,分别称SMAD1～ 8。SMAD1、2、3、5和 8属于一类 ,它们被TGF β的受体或BMP的受体激活而磷酸化 ,称为受体调节SMAD ,传导TGF β或BMP的信号。SMAD6和 7属于另一类 ,它们抑制受体调节SMAD的信号传导。SMAD4是第三类 ,它是受体调节SMAD传导信号的伴侣。受体调节SMAD传导信号必须先与SMAD4结合形成异源复合物 ,才能进到核中 。A family of SMAD proteins compose of SMAD1 to SMAD8 was recently identified as intracellular signaling protein.conducting TGF\|β.The members of the SMAD proteins can be categorized into three subgroups.SMAD1,2,3,5,and 8which are called receptor\|regulated SMADs belong to the subgroup contained the SSXS motif at the C\|terminus which can be phosphorylated by the receptors of TGF\|β or BMPs,and mediate TGF\|β or BMPs signals.The second subgroup is SMAD4 which is indispensable for the receptor\|regulated SMADs signaling.The receptor\|regulated SMADs must form hetero\|oligomeric complex with SMAD4 before mediating the signals.While SMAD6 and SMD7 belong to the third class that differ from the receptor\|regulated subgroup as they lack the SSXS motif.They inhibit TGF\|β superfamily mediating phosphorylation of receptor\|regulated SMADs.\;

关 键 词：信号传导 TGFβ超家族 SMAD蛋白家族 细胞内传导 

分 类 号：Q257[生物学—细胞生物学] Q26