健胃愈疡颗粒联合奥美拉唑治疗消化性溃疡20例疗效观察  

Clinical efficacy of Jianwei Yuyang granules combined with omeprazole in treatment of peptic ulcer:a report of 20 cases

作　　者：周兵[1] 蔡光先[1] 柏正平[1] 曾松林[1] 李家邦[2] 戴幸平[2] 

机构地区：[1]湖南省中医药研究院附属医院,湖南长沙410006 [2]中南大学湘雅医院,湖南长沙410008

出　　处：《湖南中医杂志》2013年第6期10-13,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省自然科学基金资助项目(编号:01JJY2135)

摘　　要：目的:探讨健胃愈疡颗粒联合奥美拉唑肠溶片治疗消化性溃疡(PU)的临床疗效。方法:将120例PU患者随机分为6组,幽门螺杆菌阴性(Hp-)PU健胃愈疡颗粒组(J-组)、Hp-PU奥美拉唑组(O-组)、Hp-PU健胃愈疡颗粒+奥美拉唑组(JO-组)、Hp+PU健胃愈疡颗粒组(J+组)、Hp+PU奥美粒唑组(O+组)、Hp+PU健胃愈疡颗粒+奥美拉唑组(JO+组),每组20例。J+组、J-组服用健胃愈疡颗粒治疗,O+组、O-组服用奥美拉唑治疗,JO+组、JO-组服用健胃愈疡颗粒+奥美拉唑治疗。用药1个月后观察比较6组临床疗效、胃镜疗效、Hp清除率及中医证候疗效。结果:JO+组、JO-组在临床疗效及中医证候疗效方面优于O+组和O-组(P<0.01,P<0.05);各组在胃镜疗效、Hp清除率方面比较,差异均无统计学意义(P>0.05)。结论:健胃愈疡颗粒+奥美拉唑治疗PU具有明显优势。Objective：To investigate the clinical efficacy of Jianwei Yuyang granules combined with enteric - coated tablets of omeprazole in the treatment of peptic ulcer （PU）. Methods：A total of 120 PU patients were randomly and equally divided into six groups ： J- group who were Helicobacter pylori （Hp） - negative and received Jianwei Yuyang granules, O^- group who were Hp -negative and received omeprazole, JO^- group who were Hp - negative and received Jianwei Yuyang granules plus omeprazole, J^＋ group who were Hp - positive and received Jianwei Yuyang granules, O^＋ group who were Hp-positive and received omeprazole, and JO ^＋ group who were Hp-positive and received Jianwei Yuyang granules plus omeprazole. After one month of medication, the six groups were compared in terms of the treatment outcomes evaluated clinically, by gastroscopy, and according to traditional Chi- nese medicine （TCM） syndromes as well as Hp clearance rate~ Results：Compared with the O^＋ and O^- groups, the JO ^＋ and JO^- groups had significantly better treatment outcomes evaluated clinically and according to TCM syn- dromes （P 〈 0. 05 or P 〈 0. 01 ）. There were no significant differences in treatment outcome evaluated by gastroscopy and Hp clearance rate between all groups （P 〉 0. 05 ）. Conclusion： Jianwei Yuyang granules combined with omeprazole have significantly improved clinical efficacy in the treatment of PU.

关 键 词：消化性溃疡 中西医结合疗法 健胃愈疡颗粒 奥美拉唑 

分 类 号：R259.731[医药卫生—中西医结合]