布拉酵母防治病原微生物感染的机制及效果  

Mechanisms and application of Saccharomyces boulardii against pathogens in gastrointestinal tract

作　　者：伍代朝[1,2,3] 滕达[2,3] 胡小媛[2,3] 戴华[1] 王建华[2,3] 

机构地区：[1]扬州大学医学院,江苏扬州225001 [2]农业部饲料生物技术重点开放实验室,北京100081 [3]中国农业科学院饲料研究所基因室,北京100081

出　　处：《中国微生态学杂志》2013年第6期723-726,共4页Chinese Journal of Microecology

基　　金：十二五支撑计划课题(2013BAD10B02;2011BAD10B02);中国农业科学院基本科研业务费项目"饲用布拉酵母制剂研制与开发"(1610032012042)

摘　　要：肠杆菌科细菌、霍乱弧菌、难辨梭菌、幽门螺杆菌和原虫等病原体感染是引起腹泻的主要原因。布拉酵母作为一种益生菌,通过抗微生物、免疫调节、肠道屏障、增加肠道营养等方面维持肠道微生态平衡。该酵母用于治疗肠杆菌科细菌、霍乱弧菌等病原菌感染引起的急性腹泻,能显著降低腹泻频率,缩短腹泻时间;而作为辅助药物联合抗生素治疗难辨梭菌、幽门螺杆菌和原虫等顽固性病原微生物感染,具有提高根除率、减少副作用、降低复发率的作用。本研究综述了布拉酵母对若干腹泻病原体的防治机制和临床应用研究进展。Infections caused by pathogens such as Enterobacteriaceae bacteria,Vibrio cholera,Clostridium difficile,Helicobacter pylori and Protozoa are the main causes of diarrhea.Saccharomyces boulardii,a kind of probiotics,can maintain the balance of intestinal microecology through its antimicrobial activity,immune regulation,formation of intestinal barrier,and increase of nutrients.This yeast could significantly reduce the frequency of acute diarrhea caused by Enterobacteriaceae bacteria and Vibrio cholera infections,shorten the diarrhea episodes;And as a supportive drug combined with antibiotics against persistent infections by pathogens such as Clostridium difficile,Helicobacter pylori and Protozoa,it could improve the rate of eradication,reduce side effects and recurrence rate.The mechanisms and application of Saccharomyces boulardii against the above several pathogens were reviewed in this paper.

关 键 词：布拉酵母 难辨梭菌 幽门螺杆菌 腹泻 

分 类 号：R379.4[医药卫生—病原生物学]