浓缩地鼠肾细胞狂犬病疫苗与纯化Vero细胞狂犬病疫苗接种人体的血清学效果观察  

Serological effect comparison between concentrated primary hamster kidney cell rabies vaccines(CPRV)and purified Vero cell rabies vaccines(PVRV)

作　　者：刘瑜瑄[1] 李淑云[1] 黄浩[1] 星海 

机构地区：[1]北京生物制品研究所,北京100024

出　　处：《微生物学免疫学进展》2000年第3期23-25,共3页Progress In Microbiology and Immunology

摘　　要：为了解国产浓缩地鼠肾细胞狂犬病疫苗与法国纯化Vero细胞狂犬病疫苗接种人体后中和抗体产生情况。分别用两种疫苗接种 1 0人 ,用小鼠中和试验方法检测中和抗体滴度。国产疫苗五针全程免疫后 30天 (第一针接种后 6 0天 )可 1 0 0 %达到保护水平 ,法国疫苗在第一针接种后 30天 1 0 0 %达到保护水平。第一针接种后 1 4、30、6 0天时 ,前者抗体平均滴度分别是 0 0 6IU /ml、1 .0 2IU/ml、2 .0 7IU/ml;后者抗体平均滴度分别是 0 2 5IU /ml、3.2 4IU/ml、1 1 .86IU/ml,后者比前者产生抗体的滴度高 ,具有显著性差异 (P <0 0 2 )。Two kinds of vaccin were injected separately in two groups of volunteer.Every group has ten persons. The neutralizing antibody of sera was detected according to mouse neutralization test. The result showed that CPRV may achived 100% protection level 60 days after the first injection, and PVRV could attain it 30 days. Mean antibody value of CPRV was 0.06IU/ml、1.02IU/ml、2.07IU/ml respeclively 14、30、60 days after the first injection and PVRV was 0.25IU/ml、3.24IU/ml、11.86IU/ml. The latter was clearly higher than the former. There is a significant difference between the different vaccine groups (P<0.02).

关 键 词：地鼠肾细胞 狂犬病疫苗 VERO细胞 中和抗体滴度 

分 类 号：R392.1[医药卫生—免疫学]