心肌脂肪酸结合蛋白在早期急性心肌梗死诊断中的临床价值  

Clinic value of heart-type fatty acid-binding protein on diagnosis of early acute myocardial infarction

作　　者：谢明水[1] 刘杨[1] 刘国政[1] 张秋莹[1] 黄宏耀[1] 张振建[2] 

机构地区：[1]随州市中心医院检验科,湖北随州441300 [2]随州市中心医院心血管内科,湖北随州441300

出　　处：《中国实验诊断学》2013年第6期1019-1021,共3页Chinese Journal of Laboratory Diagnosis

基　　金：湖北省卫生厅资助项目(2009JX4B69)

摘　　要：目的探讨心肌脂肪酸结合蛋白(H-FABP)在早期急性心肌梗死(AMI)诊断中的临床价值。方法检测111例0-3h内和0-6h内胸痛发作患者的血清H-FABP、cTnI和CK-MB水平,其中急性心肌梗死(AMI)40例、非急性心肌梗死(NO-AMI)36例、非心源性胸痛(NCCP)35例,同期选择37例体检健康者为对照组。比较各组0-3h内和0-6h内胸痛发作患者H-FABP的表达水平,观察H-FABP、cTnI和CK-MB诊断AMI的敏感性和特异性。结果 0-3h内和0-6h内AMI组H-FABP水平表达(38.14±24.18)ng/mL和(73.35±56.73)ng/mL均明显高于其他各组(P<0.01);H-FABP诊断发病3h和6h内AMI的敏感性显著高于cTnI和CK-MB(P<0.05),特异性比较无显著差异性(P>0.05)。结论 H-FABP诊断早期急性心肌梗死的敏感性优于cTnI和CK-MB,可作为一种有效诊断指标。Objective To investigate the clinic value of heart-type fatty acid-binding protein（H-FABP） on diagnosis of early acute myocardial infarction.Methods The H-FABP、cTnI and CK-MB levels were measured within 3h or within 6h after onset of chest pain in 111 patients.With 40 cases of acute myocardial infarction（AMI）,36 cases of no-acute myocardial infarction（NO-AMI）,35 cases of non-cardiac chest pain（NCCP）,at the same period 27 healthy volunteers were selected as the control group.The expression levels of H-FABP in within 3h or within 6h after onset of chest pain patients were compared,and the sensitivity and specificity of H-FABP,cTnI and CK-MB on diagnosis of AMI.Results The expression levels of H-FABP within 0-3 h and 0-6 h [（38.14±24.18） ng/mL and（73.35±56.73） ng/mL] were significantly higher than those of the other groups（P0.01）.The sensitivity of H-FABP in diagnosis of AMI within 0-3 h and 0-6 h were significantly higher than those of cTnI and CK-MB（P0.05）.There was no significant difference between the specificity（P0.05）.Conclusion The sensitive of H-FABP in diagnosis of early acute myocardial infarction was more than that of cTnI and CK-MB.It could be used as an effective diagnostic index.

关 键 词：心肌脂肪酸结合蛋白 急性心肌梗死 心肌肌钙蛋白I 肌酸激酶同工酶 

分 类 号：R542.22[医药卫生—心血管疾病]