咽舒宁颗粒抗炎药效试验研究  

Anti-inflammatory effect of Yanshuning Granules

作　　者：罗友华[1] 杨辉[1] 黄亦琦[1] 孙朗[1] 曾伟成[1] 许光辉[1] 

机构地区：[1]福建省厦门市医药研究所厦门市天然药物研究与开发重点实验室

出　　处：《海峡药学》2013年第6期18-21,共4页Strait Pharmaceutical Journal

基　　金：福建省医学创新课题(No.2012-CXB-40);厦门市科技计划指导性项目(No.ZD2011S0554)

摘　　要：目的观察咽舒宁颗粒的抗炎作用。方法将实验动物随机分为对照、阳性药和咽舒宁颗粒高、中、低剂量组(8.25,4.12,2.06 g.kg-1),ig 7 d,采用醋酸致小鼠腹腔毛细血管通透性实验、角叉菜胶性足肿胀实验和棉球肉芽肿实验,观察其对不同炎症模型的作用。结果咽舒宁颗粒能明显抑制醋酸致小鼠腹腔毛细血管通透性增高(P<0.05或P<0.01);显著抑制大鼠角叉菜胶性足肿胀程度(P<0.05或P<0.01)和大鼠棉球肉芽肿的形成(P<0.05或P<0.01)。结论咽舒宁颗粒具有明显的抗急慢性炎症作用。OBJECTIVE To study the anti-inflammatory effect of Yanshuning Granules. METHODS Mice were divided into six groups randomly：normal control group, two positive groups, high dose group, middle dose group and low dose group of Yanshuning granules（8.25,4. 12,2.06 g· kg^-1 ） ,after 7d by ig administration. The effects of Yanshuning Granules on different inflammation models were studied by mice acetic acid-induced celiac capillary permeability,earrageenan-induced rat foot edema and cotton pellet-induced granuloma. RESULTS Yanshuning Granules could significantly inhibite the degree of the increase in celiac capillary permeability（ P 〈 0. 05 or P 〈 0. 01 ）, markly inhibit the degree of the increase in carrageenan-induced rat foot edema（P 〈 0. 05 or P 〈 0. 01 ） and obviously reduce cotton pellet-induced granuloma（P 〈0. 05 or P 〈0. 01 ）. CONCLUSION Yanshuning Granules has significant resistance of acute or chronic inflammation.

关 键 词：咽舒宁颗粒 药效学 抗炎 毛细血管通透性 足肿胀 肉芽肿 

分 类 号：R969.4[医药卫生—药理学]