高糖诱发氧化应激导致血管内皮细胞凋亡机制研究  

Studies on the mechanisms for oxidative stress and endothelial cell apoptosis induced by high glucose

作　　者：任蓓[1] 潘澄[1] 林鹏[1] 吴斐华[1] 马世平[1] 

机构地区：[1]中国药科大学中药药理教研室,南京211198

出　　处：《海峡药学》2013年第6期268-271,共4页Strait Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81102862);国家基础科学人才培养基金项目(J0630858);2012年国家级大学生创新创业训练计划项目(G12128)

摘　　要：糖尿病是一组由于遗传因素和环境因素共同作用而导致的临床综合征,其血管并发症是导致糖尿病患者致死和致残的主要原因。血管内皮细胞凋亡在糖尿病血管并发症的发生发展过程中起重要作用。高糖能诱发氧化应激,通过一系列复杂的信号通路,如NF-κB信号通路、JNK信号通路、PI3K/AKT信号通路等直接或间接引起血管内皮细胞凋亡。改善高糖诱导的细胞凋亡可能成为治疗糖尿病及其各种并发症的一种有效途径。Diabetes mellitus is a complex metabolic syndrome which caused by a group of genetic and environmental factom,its vascular complications are a major reason that leads to patients＇ death and disabled. Endothelial cells apoptosis plays on important role in the development of diabetic vascular complications. Oxidative stress activated by high glucose are involved several pathways which can induce endothelial cell apoptosis,, such as NF-KB, JNK, PI3K/AKT and so on. Ameliorating the apoptosis of endothelial cell induced by high glucose will be an effective way for curing diabetes and its complications.

关 键 词：高糖 血管内皮细胞 细胞凋亡 糖尿病 

分 类 号：R284[医药卫生—中药学]