逐瘀通脉胶囊治疗单纯高甘油三脂血症作用观察  

Effect observation of Zhuyutongmai capsule on pure hypertriglyceridemia

作　　者：孙磊[1] 卢颖[2] 

机构地区：[1]吉林大学第四医院心内科,吉林长春130011 [2]吉林大学第四医院老年病科,吉林长春130011

出　　处：《中国医药科学》2013年第12期85-86,共2页China Medicine And Pharmacy

摘　　要：目的观察逐瘀通脉胶囊降低甘油三酯水平作用及安全性。方法回顾性分析56例诊断单纯高甘油三酯血症患者服用逐瘀通脉胶囊(26例)或非诺贝特(30例)治疗后甘油三酯水平下降及安全性差异。所有患者均于用药前及用药后4周采血化验甘油三酯、血肌酐、丙氨酸氨基转移酶、谷氨酰转肽酶、肌酸激酶。数据通过统计学分析判断不同药物治疗后上述指标变化有无差异。结果 56例患者甘油三酯水平均明显下降,逐瘀通脉胶囊治疗组及非诺贝特治疗组甘油三酯降低水平无显著差异,口服逐瘀通脉胶囊者无血肌酐、丙氨酸氨基转移酶、谷氨酰转肽酶、肌酸激酶水平异常增高及不适症状,口服非诺贝特者6例出现丙氨酸氨基转移酶升高,升高幅度<正常上限2倍;4例患者出现轻微消化道不适。结论逐瘀通脉胶囊减低甘油三酯作用不劣于非诺贝特,相对具有更好的安全性及耐受性。Objective To observe the clinical efficacy and safety of zhuyutongmai capsule on lowering triglyceride level. Methods The differences of triglyceride level decreasing and safety in 56 patients with pure hypertriglyceridemia were analyzed retrospectively,and of all 26 cases were treated with zhuyutongmai capsule and 30 cases were treated with fenofibrate.The levels of blood TG,Ucr,ALT, /-GT and CK in all patients were measured before the treatment and after 4 weeks of the treatment.These indexes changes had or not difference after different drugs treatment were statisticaliy determined and analyzed. Results The le.vels of serum TG decreased significantly in 56 patients,and there was no significant difference on the decreasing levels of TG between zhuyntongmai capsule treatment group and fenofibrate treatment group.No the abnormal increasing levels of Ucr,ALT, ~ -GT and CK and uncomfortable symptoms happened in the group treated with zhuyutongmai capsule.But in the group treated with fenofibrate,the ALT levels of 6 cases increased and the increasing level were below 2 times normal upper limit;4 cases happened mildly gastrointestinal discomfortable. Conclusion Zhuyutongmai capsule on lowering triglyceride level is not worse than fenofibrate.and it has better security and tolerance.

关 键 词：逐瘀通脉胶囊 非诺贝特 高甘油三酯血症 

分 类 号：R969.4[医药卫生—药理学]