血浆N末端脑利钠肽前体对多发伤患者伤情评估及对合并心肌损害的关系研究  

Effects of NT -proBNP on injury assessment of multiple trauma and its correlation with myocardial damage

作　　者：胡检[1] 黄志斌[1] 柳晖[1] 陈武鹏[1] 黄宇斌[1] 苏永胜[1] 林加辉[1] 

机构地区：[1]南方医科大学附属深圳宝安医院烧伤整形科,广东深圳518101

出　　处：《中国现代医生》2013年第18期104-105,107,共3页China Modern Doctor

基　　金：广东省深圳市科技计划项目(201103070)

摘　　要：目的研究血浆NT-proBNP对多发伤患者伤情评估以及与合并心肌损害的关系。方法选择在我院就诊的多发伤合并大面积烧伤患者作为研究对象,根据烧伤程度分为Ⅰ度烧伤组、浅Ⅱ度烧伤组、深Ⅱ度烧伤组、Ⅲ度烧伤组,检测血浆NT-proBNP水平及心功能相关指标。结果 NT-proBNP水平呈现Ⅰ度烧伤组<浅Ⅱ度烧伤组<深Ⅱ度烧伤组<Ⅲ度烧伤组的趋势,NT-proBNP<125 ng/L组的心功能指标明显优于NT-proBNP≥125 ng/L组;NT-proBNP水平与烧伤深度、LVEDD、LVEF呈正相关,与ST段抬高程度呈负相关。结论血浆NT-proBNP水平与烧伤程度、心功能情况密切相关,对于多发伤患者的伤情评估具有积极价值。Objective To study the effects of NT-proBNP on severity assessment of multiple injury and its correlation with myocardial damage. Methods Multiple trauma patients with large area bum were collected and divided into Ⅰ, superficial Ⅱ, deep Ⅱ, Ⅲ degree group. Then the levels of NT-proBNP and cardiac function related indexes were detected. Results NT-proBNP level showed the trends of Ⅰ group〈superficial II group〈deep Ⅱ group〈Ⅲ degree group, and cardiac function related indexes of NT-proBNP 〈 125 ng/L group were significant better than NT-proBNP≥ 125 ng/L group; NT-proBNP level were positively correlated with depth of burn, LVEDD, LVEF and negatively correlated with elevation ST segment. Conclusion Level of NT-proBNP has positive value for injury assessment of multiple trau- ma for it is closely correlated with burn degree and heart function.

关 键 词：脑利钠肽 多发伤 大面积烧伤 心功能 

分 类 号：R459.7[医药卫生—急诊医学]